Overdrilling increases the risk of screw perforation in locked plating of complex proximal humeral fractures - A biomechanical cadaveric study.

Locked plating of proximal humerus fractures (PHF) is associated with high failure rates (15-37%). Secondary screw perforation is a prominent mode of failure for PHF and typically requires reoperation. The anatomical fracture reduction is an essential factor to prevent fixation failure. However, recent studies indicate that the risk of secondary screw perforation may increase if the articular surface is perforated during predrilling of the screw boreholes (overdrilling). This study aimed to determine whether overdrilling increases the risk of secondary screw perforation in unstable PHF. Nine pairs of human cadaveric proximal humeri were osteotomized to simulate a malreduced and highly unstable 3-part fracture (AO/OTA 11 B1.1), followed by their assignment to two study groups for overdrilling or accurate predrilling in paired design, and fixation with a locking plate. Overdrilling was defined by drilling the calcar screw's boreholes through the articular surface. All humeri were cyclically loaded to screw perforation failure. Number of cycles to initial screw loosening and final perforation failure were analysed. The accurately predrilled group revealed a significantly higher number of cycles to both initial screw loosening (p < 0.01) and final screw perforation failure (p = 0.02), compared to the overdrilled one. This is the first study reporting that drilling to the correct depth significantly increases endurance until screw perforation failure during cyclic loading after locked plating in a highly unstable PHF model. Prevention of overdrilling the boreholes could help reduce failure rates of locked plating. Future work should investigate the prevalence and consequences of overdrilling in clinics.