DNA修复和复制蛋白在衰老和肥胖中的多方面作用。
The multifaceted roles of DNA repair and replication proteins in aging and obesity.
作者信息
D'Amico Alexandra M, Vasquez Karen M
机构信息
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Boulevard, Austin, TX, 78723, USA.
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Boulevard, Austin, TX, 78723, USA.
出版信息
DNA Repair (Amst). 2021 Mar;99:103049. doi: 10.1016/j.dnarep.2021.103049. Epub 2021 Jan 21.
Abstract
Efficient mechanisms for genomic maintenance (i.e., DNA repair and DNA replication) are crucial for cell survival. Aging and obesity can lead to the dysregulation of genomic maintenance proteins/pathways and are significant risk factors for the development of cancer, metabolic disorders, and other genetic diseases. Mutations in genes that code for proteins involved in DNA repair and DNA replication can also exacerbate aging- and obesity-related disorders and lead to the development of progeroid diseases. In this review, we will discuss the roles of various DNA repair and replication proteins in aging and obesity as well as investigate the possible mechanisms by which aging and obesity can lead to the dysregulation of these proteins and pathways.
摘要
高效的基因组维持机制（即DNA修复和DNA复制）对细胞存活至关重要。衰老和肥胖会导致基因组维持蛋白/通路失调，是癌症、代谢紊乱及其他遗传疾病发生的重要风险因素。编码参与DNA修复和复制的蛋白质的基因突变也会加剧与衰老和肥胖相关的疾病，并导致早衰症的发生。在本综述中，我们将讨论各种DNA修复和复制蛋白在衰老和肥胖中的作用，并研究衰老和肥胖导致这些蛋白及通路失调的可能机制。
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