Kim Jieun, Koh Hyebin, Zhen Xing, Lee Dong-Seok, Ha Hye-Yeong, Lee Jong-Hee
Futuristic Animal Resource & Research Center (FARRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Futuristic Animal Resource & Research Center (FARRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea.
Stem Cell Res. 2021 Mar;51:102199. doi: 10.1016/j.scr.2021.102199. Epub 2021 Jan 26.
Human induced pluripotent stem cells with indefinite propagation in vitro provide a potential donor source of cells including erythroid cells for human therapy. Since group O D-negative (RhD) blood cells are considered as universal donors for transfusion, it is compelling to derive iPSC line from group O/RhD sample as a new cellular source to generate universal RBCs. The resulting iPSC line derived from group O/RhD somatic source showed typical features of pluripotent stem cells and could provide an unprecedented cellular tool to develop universal therapeutics for blood transfusion.
能够在体外无限增殖的人诱导多能干细胞为包括红细胞在内的细胞治疗提供了潜在的供体来源。由于O型D阴性（RhD）血细胞被视为输血的通用供体，因此从O型/RhD样本中获得诱导多能干细胞系作为一种新的细胞来源来生成通用红细胞具有重要意义。从O型/RhD体细胞来源获得的诱导多能干细胞系表现出多能干细胞的典型特征，可为开发通用输血治疗方法提供前所未有的细胞工具。
