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细菌对草甘膦的适应：酶 5-烯醇丙酮酰莽草酸-3-磷酸合酶的微观进化视角。

Adaptation of bacteria to glyphosate: a microevolutionary perspective of the enzyme 5-enolpyruvylshikimate-3-phosphate synthase.

机构信息

Department of Biology, University of Turku, Turku, Finland.

Biodiversity Unit, University of Turku, Turku, Finland.

出版信息

Environ Microbiol Rep. 2021 Jun;13(3):309-316. doi: 10.1111/1758-2229.12931. Epub 2021 Feb 2.

DOI:10.1111/1758-2229.12931
PMID:33530134
Abstract

Glyphosate is the leading herbicide worldwide, but it also affects prokaryotes because it targets the central enzyme (5-enolpyruvylshikimate-3-phosphate, EPSP) of the shikimate pathway in the synthesis of the three essential aromatic amino acids in bacteria, fungi and plants. Our results reveal that bacteria may easily become resistant to glyphosate through changes in the 5-enolpyruvylshikimate-3-phosphate synthase active site. This indicates the importance of examining how glyphosate affects microbe-mediated ecosystem functions and human microbiomes.

摘要

草甘膦是全球领先的除草剂，但它也会影响原核生物，因为它靶向于芳香族氨基酸生物合成途径中的 5-烯醇丙酮酰莽草酸-3-磷酸（EPSP）合酶，这是细菌、真菌和植物中三种必需芳香族氨基酸合成的关键酶。我们的研究结果表明，细菌可能会通过改变 5-烯醇丙酮酰莽草酸-3-磷酸合酶的活性位点，从而轻易地对草甘膦产生抗性。这表明研究草甘膦如何影响微生物介导的生态系统功能和人类微生物组的重要性。

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