De Angelis Antonella, Urbanek Konrad, Cappetta Donato, Piegari Elena, Ciuffreda Loreta Pia, Rivellino Alessia, Russo Rosa, Esposito Grazia, Rossi Francesco, Berrino Liberato
Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, via Costantinopoli 16, 80138, Naples, Italy.
Cardiooncology. 2016 Mar 3;2(1):2. doi: 10.1186/s40959-016-0012-4.
The cardiotoxicity of doxorubicin is becoming an interdisciplinary point of interest given a growing population of cancer survivors. The complex and not completely understood pathogenesis of this complication makes difficult to design successful preventive or curative measures. Although cardiomyocyte has been considered a classical cellular target, other cells including various types of undifferentiated cells are involved in myocardial homeostasis. Such perspective may shed light on previously unrecognized aspects of cardiotoxicity and promote new experimental and clinical cardioprotective strategies. In this review, different cellular targets of doxorubicin are discussed with the focus on cardiac progenitor cells, oxidative stress, DNA damage, senescence and apoptosis all of which contribute to their compromised functional properties.
鉴于癌症幸存者群体不断扩大，阿霉素的心脏毒性正成为一个跨学科的研究热点。这种并发症的发病机制复杂且尚未完全明确，这使得设计成功的预防或治疗措施变得困难。尽管心肌细胞一直被视为经典的细胞靶点，但包括各种未分化细胞在内的其他细胞也参与了心肌稳态。这种观点可能会揭示心脏毒性以前未被认识的方面，并促进新的实验和临床心脏保护策略的发展。在这篇综述中，我们讨论了阿霉素的不同细胞靶点，重点关注心脏祖细胞、氧化应激、DNA损伤、衰老和凋亡，所有这些都导致了它们功能特性的受损。
