Department of Neurology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 85-094 Bydgoszcz, Poland.
Center of Neurology, Vilnius University, LT-08661 Vilnius, Lithuania.
Int J Environ Res Public Health. 2021 Jan 26;18(3):1079. doi: 10.3390/ijerph18031079.
: Epilepsy associated with strokes is a significant clinical and public health problem and has a negative impact on prognosis and clinical outcome. A late epileptic seizure occurring seven days after stroke is actually equated with poststroke epilepsy due to the high risk of recurrence. Predictive models evaluated in the acute phase of stroke would allow for the stratification and early selection of patients at higher risk of developing late seizures. : The most relevant papers in this field were reviewed to establish multifactorial predictors of late seizures and attempt to standardize and unify them into a common prognostic model. : Clinical and radiological factors have become the most valuable and reproducible predictors in many reports, while data on electroencephalographic, genetic, and blood biomarkers were limited. The existing prognostic models, CAVE and SeLECT, based on relevant, readily available, and routinely assessed predictors, should be validated and improved in multicenter studies for widespread use in stroke units. : Due to contradictory reports, a common and reliable model covering all factors is currently not available. Further research might refine forecasting models by incorporating advanced radiological neuroimaging or quantitative electroencephalographic analysis.
: 与中风相关的癫痫是一个重大的临床和公共卫生问题，对预后和临床结果有负面影响。中风后 7 天发生的迟发性癫痫实际上等同于中风后癫痫，因为其复发风险很高。在中风急性期评估的预测模型将允许对具有更高发生迟发性发作风险的患者进行分层和早期选择。 : 为了确定迟发性发作的多因素预测因素，并尝试将其标准化和统一到一个通用的预后模型中，对该领域的最相关论文进行了综述。 : 在许多报告中，临床和影像学因素已成为最有价值和可重复的预测因素，而关于脑电图、遗传和血液生物标志物的数据则有限。现有的基于相关、易于获得和常规评估的预测因素的预后模型 CAVE 和 SeLECT 应在多中心研究中进行验证和改进，以便在中风病房中广泛使用。 : 由于报告存在矛盾，目前尚无涵盖所有因素的通用和可靠模型。进一步的研究可能通过纳入先进的影像学神经影像学或定量脑电图分析来完善预测模型。
