Daniel A G, Peters W A
Department of Obstetrics and Gynecology, University of Washington Medical Center, Seattle.
Obstet Gynecol. 1988 Apr;71(4):612-4.
This retrospective study reviewed the records of 375 patients with clinical stage I adenocarcinoma of the endometrium. After criteria for exclusion were applied, 223 patients were analyzed further. Results from office and operating room curettage were compared with findings at hysterectomy. Twenty percent of cases showed an increase in grade at hysterectomy after office curettage; 15% showed upgrading after operating room curettage, a nonsignificant difference. We conclude that the techniques have equivalent accuracy in the determination of tumor grade. However, despite their well-documented reliability in tumor detection, a 15-20% upgrade suggests that frozen section confirmation of grade and depth of invasion in the hysterectomy specimen may be necessary if further surgical staging is not already planned.
这项回顾性研究回顾了375例临床I期子宫内膜腺癌患者的记录。应用排除标准后，对223例患者进行了进一步分析。将门诊刮宫和手术室刮宫的结果与子宫切除术中的发现进行了比较。20%的病例在门诊刮宫后子宫切除时分级增加；15%的病例在手术室刮宫后分级升高，差异无统计学意义。我们得出结论，这些技术在确定肿瘤分级方面具有同等的准确性。然而，尽管它们在肿瘤检测方面的可靠性已有充分记录，但15%-20%的分级升高表明，如果尚未计划进一步的手术分期，可能有必要对子宫切除标本中的分级和浸润深度进行冰冻切片确认。
