Nabil Mohamed, El Raey Mohamed A, Abdo Walied, Abdelfattah Mohamed A O, El-Shazly Assem M, Sobeh Mansour, Mahmoud Mona F
Pharmaceutical and Fermentation Industries Development Center (PFIDC), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab 21934, Egypt.
Pharmacology Department, Faculty of Pharmacy, Deraya University, New Mina 61768, Egypt.
Antioxidants (Basel). 2021 Jan 26;10(2):176. doi: 10.3390/antiox10020176.
We have previously reported that the leaf extract of exhibited substantial antioxidant, anti-inflammatory, analgesic, and antipyretic properties in vivo. We also comprehensively characterized the active phytoconstituents and found several flavonoids and galloyl glucosides derivatives. In the current work, we explored the gastroprotective effects of the leaf extract in an indomethacin-induced ulcer model and the mechanisms involved. The rats being pretreated with the tested extract (100 and 200 mg kg) significantly prevented gastric lesions by 87.4% and 92.3%, respectively, and they had no structural derangements in the gastric mucosa. The extract significantly reduced the elevated levels of IKκB, NF-κB, TNF-α, IL-6, iNOS, and lipid peroxidation; increased the reduced level of glutathione peroxidase (GPx) activity; and reduced glutathione (GSH) in the indomethacin-induced ulcer model. The protective activities of the extract were similar in most aspects to those exerted by the known anti-ulcer drug famotidine. These activities might be attributed to the anti-inflammatory and antioxidant activities, and the reduction of iNOS levels. In conclusion, is a potential candidate for management of gastric ulcers with antioxidant properties.
我们之前曾报道，[植物名称]的叶提取物在体内表现出显著的抗氧化、抗炎、镇痛和解热特性。我们还全面表征了其活性植物成分，发现了几种黄酮类化合物和没食子酰葡萄糖苷衍生物。在当前的研究中，我们探讨了该叶提取物在吲哚美辛诱导的溃疡模型中的胃保护作用及其相关机制。用受试提取物（100和200 mg/kg）预处理的大鼠分别显著预防了87.4%和92.3%的胃损伤，且胃黏膜无结构紊乱。在吲哚美辛诱导的溃疡模型中，该提取物显著降低了IKκB、NF-κB、TNF-α、IL-6、诱导型一氧化氮合酶（iNOS）水平的升高以及脂质过氧化；提高了降低的谷胱甘肽过氧化物酶（GPx）活性水平；并增加了还原型谷胱甘肽（GSH）。该提取物的保护活性在大多数方面与已知抗溃疡药物法莫替丁所发挥的活性相似。这些活性可能归因于其抗炎和抗氧化活性以及iNOS水平的降低。总之，[植物名称]是一种具有抗氧化特性、有望用于治疗胃溃疡的候选药物。
