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Key challenges for drugs in clinical development for cholangiocarcinoma.

作者信息

Keenan Bridget P, Kelley R Kate Katie

机构信息

Division of Hematology/Oncology, Department of Medicine, University of California San Francisco and Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.

出版信息

Expert Opin Investig Drugs. 2021 Apr;30(4):285-290. doi: 10.1080/13543784.2021.1880565. Epub 2021 Feb 2.

DOI:10.1080/13543784.2021.1880565
PMID:33530767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11994244/
Abstract
摘要

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Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study.帕博利珠单抗治疗的晚期实体瘤患者肿瘤突变负荷与结局的相关性:多队列、开放标签、Ⅱ期 KEYNOTE-158 研究的前瞻性生物标志物分析。
Lancet Oncol. 2020 Oct;21(10):1353-1365. doi: 10.1016/S1470-2045(20)30445-9. Epub 2020 Sep 10.
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Hepatitis B Virus Screening and Management for Patients With Cancer Prior to Therapy: ASCO Provisional Clinical Opinion Update.癌症患者治疗前的乙型肝炎病毒筛查和管理:ASCO 临时临床意见更新。
J Clin Oncol. 2020 Nov 1;38(31):3698-3715. doi: 10.1200/JCO.20.01757. Epub 2020 Jul 27.
3
Cholangiocarcinoma 2020: the next horizon in mechanisms and management.胆管癌 2020:机制和管理的新前沿。
Nat Rev Gastroenterol Hepatol. 2020 Sep;17(9):557-588. doi: 10.1038/s41575-020-0310-z. Epub 2020 Jun 30.
4
Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study.ivosidenib 治疗 IDH1 突变、化疗耐药性胆管癌(ClarIDHy):一项多中心、随机、双盲、安慰剂对照、3 期研究。
Lancet Oncol. 2020 Jun;21(6):796-807. doi: 10.1016/S1470-2045(20)30157-1. Epub 2020 May 13.
5
Efficacy and safety of pembrolizumab for the treatment of advanced biliary cancer: Results from the KEYNOTE-158 and KEYNOTE-028 studies.派姆单抗治疗晚期胆道癌的疗效和安全性:KEYNOTE-158 和 KEYNOTE-028 研究结果。
Int J Cancer. 2020 Oct 15;147(8):2190-2198. doi: 10.1002/ijc.33013. Epub 2020 May 2.
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Hepatology. 2020 Sep;72(3):965-981. doi: 10.1002/hep.31092. Epub 2020 Aug 16.
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Cancer. 2019 Dec 15;125(24):4426-4434. doi: 10.1002/cncr.32463. Epub 2019 Aug 27.