表皮衰老和癌症中细胞极性和组织架构的调控。
Regulation of Cell Polarity and Tissue Architecture in Epidermal Aging and Cancer.
机构信息
Department Cell Biology of the Skin, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany; Department of Dermatology and Venerology, University Hospital of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Cologne Excellence Cluster on Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany; Max Planck Institute for Biology of Ageing, Cologne, Germany.
出版信息
J Invest Dermatol. 2021 Apr;141(4S):1017-1023. doi: 10.1016/j.jid.2020.12.012. Epub 2021 Jan 30.
The mammalian skin is essential to protect the organism from external damage while at the same time enabling communication with the environment. Aging compromises skin function and regeneration, which is further exacerbated by external influences, such as UVR from the sun. Aging and UVR are also major risk factors contributing to the development of skin cancer. Whereas aging research traditionally has focused on the role of DNA damage and metabolic and stress pathways, less is known about how aging affects tissue architecture and cell dynamics in skin homeostasis and regeneration and whether changes in these processes promote skin cancer. This review highlights how key regulators of cell polarity and adhesion affect epidermal mechanics, tissue architecture, and stem cell dynamics in skin aging and cancer.
哺乳动物的皮肤对于保护机体免受外界损伤至关重要，同时也使机体能够与环境进行交流。衰老会损害皮肤的功能和再生能力，而外部因素（如来自太阳的 UVR）会进一步加剧这种损害。衰老和 UVR 也是导致皮肤癌发展的主要危险因素。虽然衰老研究传统上侧重于 DNA 损伤以及代谢和应激途径的作用，但对于衰老如何影响皮肤稳态和再生中的组织架构和细胞动力学以及这些过程的变化是否会促进皮肤癌知之甚少。本综述强调了细胞极性和黏附的关键调节因子如何影响皮肤衰老和皮肤癌中的表皮力学、组织架构和干细胞动力学。
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