一种突触前蛋白是胰腺肿瘤进展的净增益。

A Presynaptic Protein Is a Net Gain for Pancreatic Tumor Progression.

机构信息

Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon. Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.

出版信息

Cancer Discov. 2021 Feb;11(2):230-232. doi: 10.1158/2159-8290.CD-20-1645.

DOI:10.1158/2159-8290.CD-20-1645

PMID:33531426

Abstract

Cancer-associated fibroblasts conduct an aberrant wound-healing response, including mechanisms that restrain and others that support tumor progression. In this issue of , Francescone and colleagues demonstrate expression of presynaptic protein NetG1 on fibroblasts in pancreatic ductal adenocarcinoma and characterize tumor-supportive functions of NetG1 in this context, including metabolic and immune-modulatory mechanisms..

摘要

肿瘤相关成纤维细胞表现出异常的创伤愈合反应，包括抑制和促进肿瘤进展的机制。在这一期的《》中，Francescone 及其同事证明了突触前蛋白 NetG1 在胰腺导管腺癌中成纤维细胞中的表达，并描述了 NetG1 在这种情况下的肿瘤支持功能，包括代谢和免疫调节机制。