Isaacson Achinoam, Barki Debra, Scherz-Shouval Ruth
Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Cancer Res. 2024 Apr 15;84(8):1185-1187. doi: 10.1158/0008-5472.CAN-24-0439.
Pancreatic cancer prevalence increases with age, and disease prognosis is poorer in older individuals. The increased prevalence is driven, undoubtedly, by the multistep accumulation of oncogenic mutations in cancer cells with age. However, fibroblasts are major constituents and key players in pancreatic cancer, and they too undergo age-related changes that may contribute to disease severity. In this issue of Cancer Research, Zabransky and colleagues set out to dissect the effect of age-related changes in pancreatic fibroblasts on pancreatic ductal adenocarcinoma growth and metastasis. They discovered that aged fibroblasts secrete GDF-15, which in turn activates AKT signaling and accelerates tumor progression. These findings provide a mechanistic role for aged fibroblasts in pancreatic cancer, underpinning the importance of normal physiologic processes in tumor progression. See related article by Zabransky et al., p. 1221.
胰腺癌的患病率随年龄增长而增加，且老年个体的疾病预后较差。患病率的增加无疑是由癌细胞中致癌突变随年龄的多步积累所驱动的。然而，成纤维细胞是胰腺癌的主要成分和关键参与者，它们也会发生与年龄相关的变化，这可能会导致疾病严重程度增加。在本期《癌症研究》中，扎布兰斯基及其同事着手剖析胰腺成纤维细胞与年龄相关的变化对胰腺导管腺癌生长和转移的影响。他们发现衰老的成纤维细胞会分泌生长分化因子15（GDF-15），进而激活AKT信号传导并加速肿瘤进展。这些发现揭示了衰老的成纤维细胞在胰腺癌中的作用机制，强调了正常生理过程在肿瘤进展中的重要性。见扎布兰斯基等人的相关文章，第1221页。
