单细胞视角揭示胰腺癌成纤维细胞异质性。

A Single-Cell Window into Pancreas Cancer Fibroblast Heterogeneity.

机构信息

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.

Department of Pathology and Immunology, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri.

出版信息

Cancer Discov. 2019 Aug;9(8):1001-1002. doi: 10.1158/2159-8290.CD-19-0576.

DOI:10.1158/2159-8290.CD-19-0576

PMID:31371323

Abstract

Cancer-associated fibroblasts (CAF) have been implicated in diverse and sometimes divergent tumor modulatory processes that can be explained only by the existence of heterogeneous CAF subsets. In this issue of , Elyada and colleagues utilize single-cell transcriptomics to resolve CAF heterogeneity in pancreatic ductal adenocarcinoma and identify a novel antigen-presenting CAF population..

摘要

癌症相关成纤维细胞 (CAF) 参与了多种不同的、有时甚至相互矛盾的肿瘤调节过程，而这些过程只能通过存在异质性的 CAF 亚群来解释。在本期的杂志中，Elyada 及其同事利用单细胞转录组学解析了胰腺导管腺癌中的 CAF 异质性，并鉴定了一种新型的抗原呈递 CAF 群体。