Meng FanYan, Ren Shuang, Meng Yun, Tao Ning, Zhang Jie
Traditional Chinese Medicine Department, The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China.
Clinical Medicine of Traditional Chinese and Western Medicine, China Medical University, Shenyang 110122, People's Republic of China.
Neuropsychiatr Dis Treat. 2021 Jan 25;17:213-220. doi: 10.2147/NDT.S287798. eCollection 2021.
Previous evidence has shown that psychological stress can trigger the onset of autoimmune disease. This study aimed to investigate the prevalence of stressful life events preceding the onset of symptoms in female primary Sjogren's syndrome (pSS) in China compared to controls and the possible associations of stressful life events with disease activity.
This was a hospital-based retrospective case-control study. Sixty-seven consecutive female pSS patients and an equal number of age-matched (± 3 years) healthy controls were recruited for assessment using the related Stressful Life Events Scale. The pSS disease activity was measured by the EULAR Sjogren's syndrome disease activity index. Data were analyzed by SPSS, version 23, using chi-square, univariate logistic regression, multiple logistic regression, and partial correlation.
A higher number of negative stressful life events before disease onset in pSS patients compared with healthy controls suggest that these play a role in increasing the risk of disease occurrence (OR = 2.59, 95% CI: 1.87-3.58, < 0.05). The number of positive life events did not differ between the two groups. Both the number and severity of the negative stressful life events were also significantly correlated with disease activity.
Patients with pSS experienced more negative stressful life events in the year preceding the onset of symptoms than controls. Negative stressful life events before symptom onset may be risk factors for pSS and may affect pSS disease activity.
先前的证据表明，心理压力可引发自身免疫性疾病。本研究旨在调查中国女性原发性干燥综合征（pSS）患者与对照组相比，症状发作前应激性生活事件的发生率，以及应激性生活事件与疾病活动的可能关联。
这是一项基于医院的回顾性病例对照研究。连续招募了67例女性pSS患者和数量相等的年龄匹配（±3岁）健康对照，使用相关的应激性生活事件量表进行评估。pSS疾病活动度采用欧洲抗风湿病联盟干燥综合征疾病活动指数进行测量。使用SPSS 23版软件，通过卡方检验、单因素逻辑回归、多因素逻辑回归和偏相关分析对数据进行分析。
与健康对照相比，pSS患者疾病发作前的负面应激性生活事件数量更多，这表明这些事件在增加疾病发生风险中起作用（OR = 2.59，95% CI：1.87 - 3.58，P < 0.05）。两组之间的积极生活事件数量没有差异。负面应激性生活事件的数量和严重程度也与疾病活动度显著相关。
pSS患者在症状发作前一年经历的负面应激性生活事件比对照组更多。症状发作前的负面应激性生活事件可能是pSS的危险因素，并可能影响pSS疾病活动度。
