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肥大性骨关节病：恶性黑色素瘤的一种次要表现。

Hypertrophic Osteoarthropathy: A Secondary Manifestation of Malignant Melanoma.

作者信息

Malaty Shiva, Gupta Aditya

机构信息

HonorHealth Internal Medicine Residency, Scottsdale, AZ, USA.

出版信息

Case Rep Rheumatol. 2021 Jan 18;2021:6691320. doi: 10.1155/2021/6691320. eCollection 2021.

DOI:10.1155/2021/6691320
PMID:33532108
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7834836/
Abstract

BACKGROUND

Hypertrophic osteoarthropathy (HOA) is a rare finding in the setting of metastatic melanoma. A majority of cases of secondary HOA involve lung malignancies. Evaluation of presenting symptoms such as polyarthralgia and clubbing followed by review of imaging studies are diagnostic steps for HOA. . We present a 60-year-old female with a history of metastatic melanoma who presented with bilateral and symmetric polyarthralgia and clubbing. A plain film radiograph demonstrated periosteal thickening involving the metacarpals and proximal phalanges as well as the distal radius and ulna, consistent with HOA. The patient was treated with nonsteroidal anti-inflammatory agents for supported care.

CONCLUSION

HOA may be a secondary manifestation of metastatic melanoma. Recognition and supportive care of this condition may lead to improved quality of life for patients.

摘要

背景

肥厚性骨关节病（HOA）在转移性黑色素瘤患者中较为罕见。大多数继发性HOA病例与肺部恶性肿瘤有关。评估如多关节痛和杵状指等症状，随后复查影像学检查是诊断HOA的步骤。我们报告一名60岁有转移性黑色素瘤病史的女性，她出现双侧对称性多关节痛和杵状指。X线平片显示掌骨、近端指骨以及桡骨和尺骨远端骨膜增厚，符合HOA表现。患者接受非甾体抗炎药治疗以进行支持性护理。

结论

HOA可能是转移性黑色素瘤的一种继发表现。认识并给予这种情况支持性护理可能会改善患者的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2d8/7834836/d06a26e2952f/CRIRH2021-6691320.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2d8/7834836/6fa522c9a869/CRIRH2021-6691320.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2d8/7834836/95c3684ecc57/CRIRH2021-6691320.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2d8/7834836/d06a26e2952f/CRIRH2021-6691320.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2d8/7834836/6fa522c9a869/CRIRH2021-6691320.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2d8/7834836/95c3684ecc57/CRIRH2021-6691320.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2d8/7834836/d06a26e2952f/CRIRH2021-6691320.003.jpg

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Hypertrophic osteoarthropathy associated with metastatic melanoma.与转移性黑色素瘤相关的肥大性骨关节病。
Melanoma Res. 2005 Dec;15(6):559-61. doi: 10.1097/00008390-200512000-00013.
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