Pourrajab Fatemeh, Hekmatimoghaddam Seyedhossein
Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Biochemistry and Molecular Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Heliyon. 2021 Jan 21;7(1):e06029. doi: 10.1016/j.heliyon.2021.e06029. eCollection 2021 Jan.
There is a concept proposing that the primitive lineages of prokaryotes, eukaryotes, and viruses emerged from the primordial pool of primitive genetic elements. In this genetic pool, transposable elements (TEs) became a source of raw material for primitive genomes, tools of genetic innovation, and ancestors of modern genes (e.g. ncRNAs, tRNAs, and rRNAs). TEs contributed directly to the genome evolution of three forms of life on the earth. TEs now appear as tools that were used to giving rise to sexual dimorphism and sex determination, lineage-specific expression of genes and tissue differentiation and finally genome stability and lifespan determination.
有一种观点认为,原核生物、真核生物和病毒的原始谱系起源于原始遗传元件的原始库。在这个基因库中,转座元件(TEs)成为原始基因组的原材料来源、遗传创新的工具以及现代基因(如非编码RNA、转运RNA和核糖体RNA)的祖先。转座元件直接促成了地球上三种生命形式的基因组进化。如今,转座元件表现为用于产生两性异形和性别决定、基因的谱系特异性表达和组织分化,以及最终基因组稳定性和寿命决定的工具。