Awan Hassaan Mehboob, Shah Abdullah, Rashid Farooq, Shan Ge
CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
Genomics Proteomics Bioinformatics. 2017 Jun;15(3):187-195. doi: 10.1016/j.gpb.2017.04.002. Epub 2017 Jun 8.
Non-coding RNAs (ncRNAs) are critical regulators of gene expression in essentially all life forms. Long ncRNAs (lncRNAs) and microRNAs (miRNAs) are two important RNA classes possessing regulatory functions. Up to date, many primate-specific ncRNAs have been identified and investigated. Their expression specificity to primate lineage suggests primate-specific roles. It is thus critical to elucidate the biological significance of primate or even human-specific ncRNAs, and to develop potential ncRNA-based therapeutics. Here, we have summarized the studies regarding regulatory roles of some key primate-specific lncRNAs and miRNAs.
非编码RNA（ncRNAs）本质上是所有生命形式中基因表达的关键调节因子。长链非编码RNA（lncRNAs）和微小RNA（miRNAs）是两类具有调节功能的重要RNA。到目前为止，许多灵长类特有的ncRNAs已被鉴定和研究。它们对灵长类谱系的表达特异性表明其具有灵长类特有的作用。因此，阐明灵长类甚至人类特有的ncRNAs的生物学意义以及开发基于ncRNA的潜在治疗方法至关重要。在这里，我们总结了一些关于关键灵长类特有的lncRNAs和miRNAs调节作用的研究。
