Department of General and Plastic Surgery, University of La Sapienza, Rome, Italy, Italy.
Plastic Surgery Unit, Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy.
J Cosmet Dermatol. 2021 May;20(5):1512-1519. doi: 10.1111/jocd.13962. Epub 2021 Feb 7.
Agarose gel filler is a natural hydrocolloid with a three-dimensional structure similar to the extracellular matrix, with gel formed by hydrogen bonds and electrostatic interactions rather than through chemical cross-linking or polymerization.
To determine efficacy and safety of 2.5% agarose gel filler for the correction of nasolabial folds.
In this split-face study, efficacy, safety, and usability of 2.5% agarose gel were compared to those of NASHA-L. Assessments included the nasolabial fold (NLF) Wrinkle Severity Rating Scale (WSRS), Global Aesthetic Improvement Scale (GAIS [blinded investigator]), subject satisfaction, safety (adverse events), and usability.
Sixty-six subjects were treated, and 46/66 (66.7%) were available for evaluation at 3 months, when mean change in WSRS was identical for both products (-1.1 ± 0.4 for 2.5% agarose; -1.1 ± 0.4 for NASHA-L). Scores for each product remained similar across all time points and began to return to baseline between 7 and 8 months. GAIS score followed a similar pattern, rising between months 7 and 8 (2.7 ± 0.6 for 2.5% agarose at month 7-3.3 ± 0.5 at month 8 and 2.7 ± 0.6 for NASHA-L at month 7-3.3 ± 0.5 at month 8). Ultrasound confirmed the longevity of both fillers between 7 and 8 months. All adverse events were transient in nature and resolved within 15 days. Most events were mild in nature, and the number of events was similar between the two fillers.
Treatment with 2.5% agarose gel resulted in improvement that persisted for between 7 and 8 months. The treatment effect was equivalent to NASHA-L.
琼脂糖凝胶填充剂是一种天然水凝胶，具有与细胞外基质相似的三维结构，通过氢键和静电相互作用形成凝胶，而不是通过化学交联或聚合。
评估 2.5%琼脂糖凝胶填充剂矫正鼻唇沟的疗效和安全性。
在这项分面研究中，比较了 2.5%琼脂糖凝胶与 NASHA-L 的疗效、安全性和可用性。评估包括鼻唇沟皱纹严重程度评分量表（WSRS）、总体美学改善量表（GAIS[盲法评估者]）、患者满意度、安全性（不良反应）和可用性。
66 例患者接受了治疗，46/66（66.7%）例患者在 3 个月时可进行评估，两种产品的 WSRS 平均变化值相同（2.5%琼脂糖组为-1.1±0.4；NASHA-L 组为-1.1±0.4）。在所有时间点，两种产品的评分均相似，并且在 7 至 8 个月之间开始恢复基线。GAIS 评分也呈现类似的模式，在 7 至 8 个月之间升高（2.5%琼脂糖组：7 个月时为 2.7±0.6，3 个月时为 3.3±0.5；NASHA-L 组：7 个月时为 2.7±0.6，3 个月时为 3.3±0.5）。超声确认两种填充物在 7 至 8 个月之间的持久性。所有不良反应均为一过性，在 15 天内消退。大多数事件为轻度，两种填充物的事件数量相似。
2.5%琼脂糖凝胶治疗可使鼻唇沟改善持续 7 至 8 个月。治疗效果与 NASHA-L 相当。
