Department of Bioengineering, University of California Los Angeles, Los Angeles, California, USA.
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, People's Republic of China.
Stem Cells Transl Med. 2021 May;10(5):681-693. doi: 10.1002/sctm.20-0361. Epub 2021 Feb 2.
Neural crest stem cells (NCSCs) are a transient population of cells that arise during early vertebrate development and harbor stem cell properties, such as self-renewal and multipotency. These cells form at the interface of non-neuronal ectoderm and neural tube and undergo extensive migration whereupon they contribute to a diverse array of cell and tissue derivatives, ranging from craniofacial tissues to cells of the peripheral nervous system. Neural crest-like stem cells (NCLSCs) can be derived from pluripotent stem cells, placental tissues, adult tissues, and somatic cell reprogramming. NCLSCs have a differentiation capability similar to NCSCs, and possess great potential for regenerative medicine applications. In this review, we present recent developments on the various approaches to derive NCLSCs and the therapeutic application of these cells for tissue regeneration.
神经嵴干细胞（NCSCs）是一种在早期脊椎动物发育过程中产生的短暂细胞群，具有干细胞特性，如自我更新和多能性。这些细胞在非神经外胚层和神经管的交界处形成，并经历广泛的迁移，随后它们有助于形成一系列不同的细胞和组织衍生物，从颅面组织到周围神经系统的细胞。神经嵴样干细胞（NCLSCs）可以从多能干细胞、胎盘组织、成体组织和体细胞重编程中获得。NCLSCs 具有与 NCSCs 相似的分化能力，在再生医学应用方面具有巨大的潜力。在这篇综述中，我们介绍了获得 NCLSCs 的各种方法的最新进展，以及这些细胞在组织再生方面的治疗应用。
