Lin Xiangyu, Zhu Liang, He Jing
Department of Pathology and Pathophysiology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Front Cell Dev Biol. 2022 May 12;10:899095. doi: 10.3389/fcell.2022.899095. eCollection 2022.
As one of the main appendages of skin, hair follicles play an important role in the process of skin regeneration. Hair follicle is a tiny organ formed by the interaction between epidermis and dermis, which has complex and fine structure and periodic growth characteristics. The hair growth cycle is divided into three continuous stages, growth (anagen), apoptosis-driven regression (catagen) and relative quiescence (telogen). And The Morphogenesis and cycle of hair follicles are regulated by a variety of signal pathways. When the signal molecules in the pathways are abnormal, it will affect the development and cycle of hair follicles, which will lead to hair follicle-related diseases.This article will review the structure, development, cycle and molecular regulation of hair follicles, in order to provide new ideas for solving diseases and forming functional hair follicle.
作为皮肤的主要附属器官之一，毛囊在皮肤再生过程中发挥着重要作用。毛囊是由表皮和真皮相互作用形成的微小器官，具有复杂精细的结构和周期性生长特征。毛发的生长周期分为三个连续阶段，即生长期（anagen）、凋亡驱动的退行期（catagen）和相对静止期（telogen）。并且毛囊的形态发生和周期受多种信号通路调控。当这些通路中的信号分子出现异常时，会影响毛囊的发育和周期，进而导致毛囊相关疾病。本文将对毛囊的结构、发育、周期及分子调控进行综述，以期为解决相关疾病及构建功能性毛囊提供新思路。
