苦皮藤全株中的细胞毒性和抗炎倍半萜
Cytotoxic and Anti-Inflammatory Sesquiterpenes from the Whole Plants of .
机构信息
School of Chinese Materia Medica and State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, People's Republic of China.
School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, People's Republic of China.
出版信息
J Nat Prod. 2021 Feb 26;84(2):247-258. doi: 10.1021/acs.jnatprod.0c00884. Epub 2021 Feb 3.
Sixteen new sesquiterpene lactones (-) along with 13 known analogues (-) were isolated from the whole plants of . The structures of - were delineated by the combination of NMR spectroscopic experiments, HRESIMS, single-crystal X-ray diffraction analyses, and ECD spectra. Compounds - showed potent cytotoxicity against Hela, HCT-116, and HepG2 cells with IC values of 0.8-2.6, 0.4-3.3, and 1.1-2.6 μM, respectively. Compounds , , and exhibited significant inhibitory activity on the production of nitric oxide in the lipopolysaccharide-activated RAW 264.7 mouse macrophage cell line, with IC values ranging from 0.1 to 0.2 μM.
从全株植物中分离得到了 16 个新的倍半萜内酯（-）和 13 个已知类似物（-）。通过 NMR 光谱实验、HRESIMS、单晶 X 射线衍射分析和 ECD 光谱的组合，确定了 - 的结构。化合物 - 对 Hela、HCT-116 和 HepG2 细胞表现出强烈的细胞毒性，IC 值分别为 0.8-2.6、0.4-3.3 和 1.1-2.6 μM。化合物 、 、和 对脂多糖激活的 RAW 264.7 小鼠巨噬细胞系中一氧化氮的产生具有显著的抑制活性，IC 值范围为 0.1-0.2 μM。
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