毛梗豨莶中的新型细胞毒性倍半萜类化合物。
New cytotoxic sesquiterpenoids from Siegesbeckia glabrescens.
作者信息
Wu Qian, Li Hua, Lee So Yoon, Lee Hwa Jin, Ryu Jae-Ha
机构信息
Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea.
Department of Natural Medicine Resources, Semyung University, Chungbuk 390-711, Korea.
出版信息
Molecules. 2015 Feb 10;20(2):2850-6. doi: 10.3390/molecules20022850.
Two new sesquiterpenoids, siegenolides A (1) and B (2), and two known sesquiterpenes 3 and 4 were isolated from Siegesbeckia glabrescens. Their structures were elucidated by spectroscopic analyses, and they were further evaluated for their cytotoxic activities against human cancer cells (MCF-7, AsPC-1, SW480, HCT 116, HepG2, HeLa). Compounds 1-4 showed differential cytotoxic effects on the target cancer cells with IC50 values in the range of 0.9-33.3 μM.
从毛梗豨莶中分离得到两个新的倍半萜类化合物，豨莶内酯A（1）和豨莶内酯B（2），以及两个已知的倍半萜3和4。通过光谱分析确定了它们的结构，并进一步评估了它们对人癌细胞（MCF-7、AsPC-1、SW480、HCT 116、HepG2、HeLa）的细胞毒性活性。化合物1-4对靶癌细胞表现出不同的细胞毒性作用，IC50值在0.9-33.3μM范围内。
Zotero 插件