Loma Linda University Medical Center, Loma Linda, CA, USA.
J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:2324709621990768. doi: 10.1177/2324709621990768.
Loperamide is an easily accessible antidiarrheal medication. Unlike other medications in its class, loperamide is unique in that it causes euphoria at supratherapeutic levels due to its effect on opioid receptors. Unfortunately, with its growing abuse potential also comes increasing reports of cardiotoxicity including prolonged QT, torsades de pointes, and sudden cardiac death. We report a case of a 29-year-old female who presented with unstable arrhythmia that further progressed into electrical storm in the setting of loperamide toxicity. Due to its growing popularity and availability, it is important for clinicians to understand loperamide's mechanisms for causing toxicity as well as how to appropriately treat its complications.
洛哌丁胺是一种易于获得的止泻药。与同类药物不同，洛哌丁胺因其对阿片受体的作用，在治疗水平以上会引起欣快感，这使其具有独特性。不幸的是，随着滥用潜力的增加，也越来越多的报告显示其具有心脏毒性，包括 QT 延长、尖端扭转型室性心动过速和心源性猝死。我们报告了一例 29 岁女性的病例，她因洛哌丁胺中毒出现不稳定的心律失常，进一步发展为电风暴。由于其日益普及和可得性，临床医生了解洛哌丁胺引起毒性的机制以及如何适当治疗其并发症非常重要。
