School of Pharmacy and Pharmaceutical Sciences, Binghamton University, Binghamton, NY, USA.
Department of Emergency Medicine, Upstate Medical University, Upstate New York Poison Center, Syracuse, NY, USA.
Clin Toxicol (Phila). 2020 May;58(5):355-359. doi: 10.1080/15563650.2019.1681443. Epub 2019 Nov 4.
This position statement is a collaborative effort by the American Academy of Clinical Toxicology (AACT) and the American Association of Poison Control Centers (AAPCC) and has been endorsed by the American College of Medical Toxicology (ACMT). The position statement describes loperamide misuse, proposed mechanisms of toxicity, adverse clinical effects, and recommendations for the acute monitoring and management of patients with loperamide toxicity. Use of high-dose loperamide for its euphoric effects and to self-treat opioid use disorder (in place of evidence-based therapies, like buprenorphine or methadone), is increasing. Despite reports in the medical literature and lay press, many remain unaware of high-dose loperamide use and how to manage patients with loperamide-associated toxicities. Providers in Emergency Medicine; Prehospital; Intensive Care; Internal Medicine; Primary Care; Gastroenterology; Addiction Medicine; Pharmacy.
本立场声明是由美国临床毒理学学会（AACT）和美国毒物控制中心协会（AAPCC）共同努力的结果，并得到了美国医学毒理学学院（ACMT）的认可。该立场声明描述了洛哌丁胺的滥用、毒性的潜在机制、不良临床影响以及对洛哌丁胺毒性患者的急性监测和管理建议。高剂量洛哌丁胺被用于其欣快作用，并替代阿片类药物使用障碍的循证治疗（如丁丙诺啡或美沙酮），其使用量正在增加。尽管在医学文献和大众媒体中有报道，但许多人仍然不知道高剂量洛哌丁胺的使用情况以及如何管理与洛哌丁胺相关的毒性患者。急诊医学、院前急救、重症监护、内科、初级保健、胃肠病学、成瘾医学、药学等领域的提供者。
