一种基于三(苯并三氮唑甲基)胺的笼状配体，可耐受外加的大体积亲核试剂，用于铜催化的叠氮-炔基环加成反应（CuAAC）。
A tris(benzyltriazolemethyl)amine-based cage as a CuAAC ligand tolerant to exogeneous bulky nucleophiles.
机构信息
Aix Marseille Univ., CNRS, Centrale Marseille, iSm2, Marseille, France.
出版信息
Chem Commun (Camb). 2021 Mar 4;57(18):2281-2284. doi: 10.1039/d0cc08005e. Epub 2021 Feb 3.
PMID:33533356
Abstract
The archetypal tris(benzyltriazolemethyl)amine (TBTA) ligand was equipped with a bowl-shaped cap in the cage Hm-TBTA. Hm-TBTA accelerates CuAAC reactions without suffering from product inhibition. Furthermore, this shielded ligand efficiently protects the copper center from deactivation by the Cu-chelator glutathione, opening the way to novel approaches for efficient CuAAC reactions in complex media.
摘要
笼状三(苯并三氮唑甲基)胺（TBTA）配体在笼状 Hm-TBTA 中配备了一个碗状帽。Hm-TBTA 可加速 CuAAC 反应，而不会受到产物抑制的影响。此外，这种屏蔽配体有效地防止铜中心被铜螯合谷胱甘肽失活，为在复杂介质中有效进行 CuAAC 反应开辟了新途径。
Zotero 插件