Liu Shan, Zhu Zhi-Qiang, Hu Zhi-Yu, Tang Juan, Yuan En
Jiangxi Province Key Laboratory of Synthetic chemistry, School of Chemistry, Biology and Material Science, East China University of Technology, Nanchang 330013, China.
Ministry of Education Key Laboratory of Functional Small Organic Molecule, Department of Chemistry and chemical engineering, Jiangxi Normal University, Nanchang 330022, China.
Org Biomol Chem. 2021 Feb 25;19(7):1616-1619. doi: 10.1039/d0ob02490b.
A novel and straightforward intramolecular cyclization of glycine derivatives to 2-substituted benzoxazoles through copper-catalyzed oxidative C-H/O-H cross-coupling was described. A variety of glycine derivatives involving short peptides underwent cross-dehydrogenative-coupling readily to afford diverse 2-substituted benzoxazoles. The synthetic method has the advantages of simple operation, broad substrate scope and mild reaction conditions, thus providing an alternative effective approach for benzoxazole construction.
描述了一种新颖且直接的通过铜催化的氧化C-H/O-H交叉偶联将甘氨酸衍生物分子内环化生成2-取代苯并恶唑的方法。多种含有短肽的甘氨酸衍生物易于发生交叉脱氢偶联反应，从而得到各种2-取代苯并恶唑。该合成方法具有操作简单、底物范围广和反应条件温和等优点，因此为苯并恶唑的构建提供了一种有效的替代方法。
