Acta Chim Slov. 2020 Dec;67(4):1227-1232.
Titanium dioxide can adhere with human epithelial cells and have good tolerability. Present work has been undertaken to explore the influence of TiO2 on mucosal permeation of aceclofenac. Mucosal permeation of aeclofenac solution containing TiO2 has been carried out. In fourier transform infrared spectrosopy (FTIR), the intensity of the peaks has decreased along with the increase of TiO2 content in the formulation indicating a possible binding between drug and TiO2. Melting enthalpy has been decreased with the increased content of TiO2 in the solid. The status of crystal strain and dislocation density of TiO2 and aceclofenac in the solid state formulation has also been evaluated from Xray Diffraction data using Debye-Scherrer's equation. Mucosal permeation of aceclofenac has shown sustained effect for more than 20 h in presence of titanium dioxide. Titanium dioxide could be used in designing formulation for sustaining mucosal aceclofenac delivery after performing risk assessment study.
二氧化钛可以与人体上皮细胞结合，具有良好的耐受性。本研究旨在探讨 TiO2 对双氯芬酸粘膜透过性的影响。进行了含有 TiO2 的双氯芬酸溶液的粘膜透过性研究。在傅里叶变换红外光谱（FTIR）中，随着制剂中 TiO2 含量的增加，峰的强度降低，表明药物与 TiO2 之间可能存在结合。随着 TiO2 含量的增加，熔融焓降低。还通过 X 射线衍射数据使用德拜-谢勒方程评估了固态制剂中 TiO2 和双氯芬酸的晶体应变和位错密度的状态。在存在二氧化钛的情况下，双氯芬酸的粘膜透过性表现出超过 20 小时的持续效果。在进行风险评估研究后，二氧化钛可用于设计维持粘膜双氯芬酸传递的制剂。
