Information Network of Departments of Dermatology (IVDK), Institute at the University Medical Center Göttingen, Göttingen, Germany.
Department of Dermatology, Bethesda Hospital, Freudenberg, Germany.
Contact Dermatitis. 2021 Jun;84(6):407-418. doi: 10.1111/cod.13803. Epub 2021 Mar 1.
In about half of the patients reacting positive to fragrance mix I (FM I), breakdown testing remains negative. This raises the question of whether the reaction to FM I is false-positive, or the breakdown test is false-negative.
To identify characteristics and sensitization patterns of patients positive to FM I, but not to its fragrance constituents.
Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK) between 2005 and 2019. Three patient groups were defined according to their reaction pattern: Group I, FM I positive and ≥1 single fragrance positive in the breakdown test (n = 1912); Group II, FM I positive and breakdown test negative (n = 1318); Group III, FM I negative (n = 19 790).
Regarding the pattern of concomitant reactions to other fragrances, Group II had an intermediate position between Group I and Group III. In other respects (age and sex distribution, frequency of sensitization to non-fragrance baseline series allergens), Group II rather resembled Group I.
Not every positive reaction to FM I in patients with negative breakdown tests is false-positive. There may be false-negative reactions to the single fragrance components when patch tested at 1% pet. Raising patch concentrations of some single fragrances is recommended.
在对香料混合物 I（FM I）呈阳性反应的患者中，约有一半的患者的成分分解测试结果仍为阴性。这就提出了一个问题，即对 FM I 的反应是假阳性，还是成分分解测试是假阴性。
确定对 FM I 呈阳性反应但对其香料成分呈阴性反应的患者的特征和致敏模式。
回顾性分析 2005 年至 2019 年期间信息网络皮肤科（IVDK）的数据。根据患者的反应模式将其分为三组：组 I，FM I 阳性且成分分解测试中有≥1 种单一香料阳性（n = 1912）；组 II，FM I 阳性且成分分解测试阴性（n = 1318）；组 III，FM I 阴性（n = 19790）。
关于其他香料同时反应的模式，组 II 处于组 I 和组 III 之间的中间位置。在其他方面（年龄和性别分布、对非香料基础系列过敏原的致敏频率），组 II 更类似于组 I。
并非所有成分分解测试呈阴性的 FM I 阳性患者的反应都是假阳性。在进行 1%浓度斑贴试验时，某些单一香料成分可能会出现假阴性反应。建议提高某些单一香料的斑贴浓度。
