Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, London, UK.
Musculoskeletal Sciences and Sports Medicine Research Centre, Manchester Metropolitan University, Manchester, UK.
Muscle Nerve. 2021 May;63(5):724-729. doi: 10.1002/mus.27192. Epub 2021 Feb 25.
Transcranial magnetic stimulation (TMS) is widely used to explore cortical physiology in health and disease. Surface electromyography (sEMG) is appropriate for superficial muscles, but cannot be applied easily to less accessible muscles. Muscle ultrasound (mUS) may provide an elegant solution to this problem, but fundamental questions remain. We explore the relationship between TMS evoked muscle potentials and TMS evoked muscle contractions measured with mUS.
In 10 participants, we performed a TMS recruitment curve, simultaneously measuring motor evoked potentials (MEPs) and mUS in biceps (BI), first dorsal interosseous (FDI), tibialis anterior (TA), and the tongue (TO).
Resting motor threshold (RMT) measurements and recruitment curves were found to be consistent across sEMG and mUS.
This work supports the use of TMS-US to study less accessible muscles. The implications are broad but could include the study of a new range of muscles in disorders such as amyotrophic lateral sclerosis.
经颅磁刺激（TMS）被广泛用于探索健康和疾病中的皮质生理学。表面肌电图（sEMG）适用于浅层肌肉，但不易用于较难触及的肌肉。肌肉超声（mUS）可能为这个问题提供了一个优雅的解决方案，但仍存在一些基本问题。我们探讨了 TMS 诱发的肌肉电位与 mUS 测量的 TMS 诱发肌肉收缩之间的关系。
在 10 名参与者中，我们同时测量肱二头肌（BI）、第一背骨间肌（FDI）、胫骨前肌（TA）和舌肌（TO）的运动诱发电位（MEP）和 mUS，进行 TMS 募集曲线测量。
发现静息运动阈值（RMT）测量值和募集曲线在 sEMG 和 mUS 之间是一致的。
这项工作支持使用 TMS-US 来研究较难触及的肌肉。其影响广泛，但可能包括在肌萎缩侧索硬化症等疾病中研究新的一系列肌肉。
