Klint T, Hillegaart V, Edlund P O, Wijkström A, Ahlenius S
Astra Alab AB, Research and Development Laboratories, Södertälje, Sweden.
Pharmacol Toxicol. 1988 Feb;62(2):64-8. doi: 10.1111/j.1600-0773.1988.tb01847.x.
In order to study the effects of castration of brain dopamine (DA) receptor sensitivity, the effects of apomorphine on locomotor activity and striatal DA synthesis, as assessed by the dihydroxyphenylalanine (DOPA) accumulation after NSD-1015 treatment, were examined in normal and castrated male Sprague-Dawley rats pretreated with reserpine (5 mg/kg-18 hrs). There was an enhanced locomotor response to apomorphine (0.05-0.1 mg/kg) in castrated animals, as compared to sham operated controls. Furthermore, the increase in DOPA accumulation produced by the reserpine treatment was antagonized to a greater extent by apomorphine in the castrated animals. These results indicate an enhanced DA receptor sensitivity at both pre- and post-synaptic sites.
为了研究去势对脑多巴胺（DA）受体敏感性的影响，在预先给予利血平（5mg/kg，18小时）的正常和去势雄性Sprague-Dawley大鼠中，检测了阿扑吗啡对运动活性和纹状体DA合成的影响，后者通过NSD-1015处理后的二羟基苯丙氨酸（DOPA）积累来评估。与假手术对照组相比，去势动物对阿扑吗啡（0.05-0.1mg/kg）的运动反应增强。此外，在去势动物中，利血平处理所产生的DOPA积累增加在更大程度上被阿扑吗啡所拮抗。这些结果表明在突触前和突触后位点DA受体敏感性均增强。
