Wilmot C A, VanderWende C, Spoerlein M T
Psychopharmacology (Berl). 1986;89(3):364-9. doi: 10.1007/BF00174376.
Group housed and individually housed mice were compared in (1) the motor activity responses to direct and indirect dopamine (DA) agonists, (2) in vivo presynaptic autoreceptor sensitivity and (3) in vitro binding of 3H-spiperone. Relative to group housed mice, individually housed mice showed an increased motor activity response to amphetamine, 1.25 and 0.625 mg/kg. Using two in vivo measures of presynaptic DA receptor sensitivity, the antagonism of spontaneous locomotor activity and the antagonism of dihydroxyphenylalanine (DOPA) accumulation by apomorphine (APO), individually housed mice showed greater activity counts and higher DOPA accumulations than group housed mice. Levels of tyrosine were significantly greater in individually housed mice. Significant effects of housing were also noted with the motor activity response to APO, 0.075-0.300 mg/kg, following pretreatment with reserpine, an in vivo measure of postsynaptic receptor sensitivity. However, there was no effect of housing on the number or affinity of 3H-spiperone binding sites in the striatum. These results are discussed in terms of the presynaptic activity of catecholaminergic neurons and the postsynaptic receptor sensitivity to APO in individually housed mice.
(1) 对直接和间接多巴胺 (DA) 激动剂的运动活动反应；(2) 体内突触前自身受体敏感性；(3) 3H-螺哌隆的体外结合。与群居小鼠相比，单独饲养的小鼠对苯丙胺（1.25 和 0.625 mg/kg）的运动活动反应增强。使用两种体内突触前 DA 受体敏感性测量方法，即阿扑吗啡 (APO) 对自发运动活动的拮抗作用以及对二羟基苯丙氨酸 (DOPA) 积累的拮抗作用，单独饲养的小鼠比群居小鼠表现出更高的活动计数和更高的 DOPA 积累。单独饲养的小鼠体内酪氨酸水平显著更高。在用利血平预处理后，对 0.075 - 0.300 mg/kg 的 APO 的运动活动反应也观察到饲养方式的显著影响，这是一种体内突触后受体敏感性测量方法。然而，饲养方式对纹状体中 3H-螺哌隆结合位点的数量或亲和力没有影响。根据单独饲养小鼠中儿茶酚胺能神经元的突触前活性以及对 APO 的突触后受体敏感性对这些结果进行了讨论。
