School of Pharmacy, Faculty of Medicine & Health, University of Sydney, NSW 2006, Australia.
Nusmetics Pte. Ltd, i4 building, 3 Research Link, Singapore 117602, Republic of Singapore.
Nanomedicine (Lond). 2021 Feb;16(4):335-349. doi: 10.2217/nnm-2020-0337. Epub 2021 Feb 3.
The rapid advancements of nanotechnology over the recent years have reformed the methods used for treating human diseases. Nanostructures including nanoneedles, nanorods, nanowires, nanofibers and nanotubes have exhibited their potential roles in drug delivery, biosensing, cancer therapy, regenerative medicine and intracellular surgery. These high aspect ratio structures enhance targeted drug delivery with spatiotemporal control while also demonstrating their role as an efficient intracellular biosensor with minimal invasiveness. This review discusses the history and emergence of these nanostructures and their fabrication methods. This review also provides an overview of the different applications of nanoneedle systems, further highlighting the importance of greater investigation into these nanostructures for future medicine.
近年来，纳米技术的快速发展改变了治疗人类疾病的方法。纳米结构，包括纳米针、纳米棒、纳米线、纳米纤维和纳米管，已经在药物输送、生物传感、癌症治疗、再生医学和细胞内手术等方面展示了其潜在的作用。这些高纵横比的结构增强了靶向药物输送的时空控制，同时也证明了它们作为一种高效的细胞内生物传感器的作用，具有最小的侵入性。本文综述了这些纳米结构的历史和出现，以及它们的制造方法。本文还概述了纳米针系统的不同应用，进一步强调了对这些纳米结构进行更多研究对未来医学的重要性。
