Materials Department, Loughborough University, Epinal Way, Loughborough, LE11 3TU, UK.
Soft Matter. 2021 Apr 14;17(14):3775-3783. doi: 10.1039/d0sm01987a. Epub 2021 Feb 3.
Inflammatory skin disorders are highly prevalent and current treatments are marred by side-effects. Here, we have designed anti-inflammatory fibrous sheets with the potential to treat low exudate inflammatory skin disorders such as psoriasis or atopic dermatitis. Antioxidant and anti-inflammatory nanoparticles composed of crosslinked poly(propylene sulfide) (PPS) were encapsulated in poly(ethylene oxide) (PEO) fibres via electrospinning from an aqueous suspension. The loading of nanoparticles did not adversely effect the homogenous nature of the electrospun fibres; furthermore, nanoparticles retained their morphology, size and anti-inflammatory character after electrospinning. The PPS-nanoparticle-loaded nanofibres were found to be highly cytocompatible when tested on human dermal fibroblasts. These findings suggest they have significant potential to topically treat inflamed tissues that are characterized by high reactive oxygen species (ROS) levels.
炎症性皮肤疾病的发病率很高，而目前的治疗方法存在副作用。在这里，我们设计了具有潜在治疗低渗出性炎症性皮肤疾病（如银屑病或特应性皮炎）的抗炎纤维片。抗氧化和抗炎纳米粒子由交联的聚（丙烯基硫醚）（PPS）组成，通过从水悬浮液中静电纺丝将其封装在聚（氧化乙烯）（PEO）纤维中。纳米粒子的负载不会对电纺纤维的均一性质产生不利影响；此外，纳米粒子在电纺后保持其形态、尺寸和抗炎特性。在人真皮成纤维细胞上进行测试时，发现负载有 PPS-纳米粒子的纳米纤维具有高度的细胞相容性。这些发现表明，它们具有治疗以高活性氧（ROS）水平为特征的炎症组织的巨大潜力。
