有证据表明，在长时程增强诱导过程中，突触之间的联合相互作用发生在局部树突域内。
Evidence that associative interactions between synapses during the induction of long-term potentiation occur within local dendritic domains.
作者信息
White G, Levy W B, Steward O
机构信息
Department of Physiology, University of Virginia, School of Medicine, Charlottesville 22908.
出版信息
Proc Natl Acad Sci U S A. 1988 Apr;85(7):2368-72. doi: 10.1073/pnas.85.7.2368.
Abstract
The present study evaluates whether the associative interactions between synapses that lead to long-term potentiation and depression (LTP and LTD) can occur between spatially segregated synapses of the medial and lateral temporodentate pathway of the rat. Coconditioning of crossed and ipsilateral pathways resulted in LTP of the crossed system only when the current sinks of the two conditioned pathways overlapped sufficiently. Likewise, conditioning of an ipsilateral pathway alone resulted in LTD of the crossed pathway only when those current sinks overlapped sufficiently. These observations support the idea that associative events that lead to LTP or LTD can be restricted to a local dendritic domain. The postsynaptic cell can therefore serve as more than one unit of integration for synaptic modification.
摘要
本研究评估了导致长时程增强和长时程抑制（LTP和LTD）的突触间联合相互作用是否能在大鼠内侧和外侧颞齿状回通路的空间分离突触之间发生。交叉和同侧通路的共条件作用仅在两条受条件作用通路的电流沉充分重叠时才导致交叉系统的LTP。同样，仅同侧通路的条件作用仅在那些电流沉充分重叠时才导致交叉通路的LTD。这些观察结果支持这样一种观点，即导致LTP或LTD的联合事件可局限于局部树突域。因此，突触后细胞可作为突触修饰的多个整合单元。
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本文引用的文献
1
Brief bursts of high-frequency stimulation produce two types of structural change in rat hippocampus.高频刺激的短暂脉冲会在大鼠海马体中产生两种结构变化。
J Neurophysiol. 1980 Aug;44(2):247-58. doi: 10.1152/jn.1980.44.2.247.
2
Inhibitory modulation of long-term potentiation: evidence for a postsynaptic locus of control.长时程增强的抑制性调节：突触后控制位点的证据。
Brain Res. 1982 May 27;240(2):259-72. doi: 10.1016/0006-8993(82)90221-9.
3
Long-term synaptic enhancement in hippocampus is not regulated by postsynaptic membrane potential.
Brain Res. 1982 Feb 4;233(1):195-9. doi: 10.1016/0006-8993(82)90941-6.
4
Partial quantification of the associative synaptic learning rule of the dentate gyrus.
Neuroscience. 1983 Apr;8(4):799-808. doi: 10.1016/0306-4522(83)90011-8.
5
Synaptic correlates of associative potentiation/depression: an ultrastructural study in the hippocampus.联合增强/抑制的突触关联：海马体的超微结构研究
Brain Res. 1983 Apr 11;265(1):21-30. doi: 10.1016/0006-8993(83)91329-x.
6
Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice.大鼠海马切片中突触活动及效能变化的瞬时和持久形态学关联
Brain Res. 1984 Aug 20;309(1):35-46. doi: 10.1016/0006-8993(84)91008-4.
7
Feed-forward inhibition in the hippocampal formation.海马结构中的前馈抑制。
Prog Neurobiol. 1984;22(2):131-53. doi: 10.1016/0301-0082(84)90023-6.
8
Associative long-term potentiation in hippocampal slices.海马切片中的联合性长时程增强
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9
Temporal contiguity requirements for long-term associative potentiation/depression in the hippocampus.海马体中长期联想性增强/抑制的时间连续性要求。
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10
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