Racine R J, Milgram N W, Hafner S
Brain Res. 1983 Feb 7;260(2):217-31. doi: 10.1016/0006-8993(83)90676-5.
Long-term potentiation (LTP) phenomena were investigated in several limbic forebrain pathways. With the possible exception of the lateral olfactory tract, LTP could be produced in all pathways tested. LTP effects tended to increase as the stimulation site moved caudally along the pyriform lobe. The largest effects were produced by stimulation of pathways into and out of the hippocampus. Target sites also differed, with the hippocampal sites showing the strongest and longest lasting LTP effects. The time course of LTP appeared to be best fitted by the sum of two exponential curves with time constants of about 1.5 h and 5 days respectively. We also looked at the potentiation effects produced by repeated epileptogenic (kindling) stimulations, and the effect of this potentiation on subsequent tests of short-term and long-term potentiation. In most cases, the short-term effects, and the first component of the LTP effect, were still intact after kindling. The longest lasting component, however, could no longer be produced with either amygdala or perforant path stimulation. This result indicates that the potentiation produced by kindling may be based upon the same mechanism as the LTP effect.
在几条边缘前脑通路中研究了长时程增强（LTP）现象。除外侧嗅束可能例外，在所测试的所有通路中均能产生LTP。随着刺激部位沿梨状叶向尾侧移动，LTP效应往往会增强。最大的效应是由刺激进出海马体的通路产生的。靶点部位也有所不同，海马体部位表现出最强且持续时间最长的LTP效应。LTP的时间进程似乎最适合用两条指数曲线之和来拟合，时间常数分别约为1.5小时和5天。我们还研究了反复的致痫（点燃）刺激所产生的增强效应，以及这种增强对随后短期和长期增强测试的影响。在大多数情况下，点燃后短期效应以及LTP效应的第一成分仍然完好无损。然而，无论是杏仁核还是穿通通路刺激，都不再能产生持续时间最长的成分。这一结果表明，点燃所产生的增强可能与LTP效应基于相同的机制。
