Monash-Epworth Rehabilitation Research Centre, Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia.
Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.
JBI Evid Synth. 2021 Jul 1;19(7):1720-1734. doi: 10.11124/JBIES-20-00363.
The objective of this review is to synthesize systematic reviews of the effectiveness of pharmacotherapy vs any other comparator for the management of post-traumatic brain injury depression in adults.
Depression following a traumatic brain injury can have a considerable impact on the life of the individual, their family members, and the health care system. There have been several recent systematic reviews and meta-analyses on pharmacologic treatment for depression caused by post-traumatic brain injury. These reviews differ in conduct, quality, and reporting, and have discordant results and conclusions. Therefore, an umbrella review can provide prescribers with a summary of the evidence.
This review will consider systematic reviews of studies of adults 16 years or older who have sustained a traumatic brain injury of any severity at any time in the past, who are receiving pharmacotherapy for depression of any severity in any health care setting. Studies that include the following outcomes will be considered: change in symptoms of depression and occurrence of harms.
MEDLINE, Embase, CINAHL, PsycINFO, Cochrane Database of Systematic Reviews, Epistemonikos, and PROSPERO will be searched, as well as Google Scholar, ResearchGate, TRIP Medical Database, and hand searching journals. There will be no restriction on publication date. Only systematic reviews published in English will be considered. Screening of articles, assessment of methodological quality, and data extraction will be performed independently by two reviewers. A Grading of Recommendations, Assessment, Development and Evaluation Summary of Findings will be presented. Data will be summarized in narrative form with supporting tables.
PROSPERO CRD42020184915.
本综述旨在综合评估药物治疗与任何其他对照药物治疗成人创伤性脑损伤后抑郁的疗效。
创伤性脑损伤后出现的抑郁会对患者、其家属和医疗保健系统产生重大影响。近年来，已有多项关于药物治疗创伤性脑损伤后抑郁的系统评价和荟萃分析。这些综述在实施、质量和报告方面存在差异，且结果和结论不一致。因此，伞式综述可以为临床医生提供证据总结。
本综述将纳入研究对象为过去任何时间因任何严重程度的创伤性脑损伤而导致的 16 岁及以上成年人，他们在任何医疗保健环境中接受任何严重程度的药物治疗来治疗抑郁的系统评价。将考虑以下结局的研究：抑郁症状的变化和不良事件的发生。
将对 MEDLINE、Embase、CINAHL、PsycINFO、Cochrane 系统评价数据库、Epistemonikos、PROSPERO 进行检索，并对 Google Scholar、ResearchGate、TRIP 医学数据库和期刊进行手工检索。不限制发表日期。仅考虑发表在英文期刊上的系统评价。两名评审员将独立筛选文章、评估方法学质量和提取数据。将呈现推荐分级评估、制定与评价（Grading of Recommendations, Assessment, Development and Evaluation，GRADE）总结发现。数据将以叙述性和表格形式进行总结。
PROSPERO CRD42020184915。
