School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK
Musculoskeletal Physiotherapy, St George's University Hospitals NHS Foundation Trust, London, UK.
BMJ Open. 2021 Oct 11;11(10):e053941. doi: 10.1136/bmjopen-2021-053941.
Recent systematic reviews have identified many biopsychosocial factors associated with the development of chronic musculoskeletal pain (CMP). Despite often being specific to a particular musculoskeletal condition, findings are similar across systematic reviews. Research is needed to aggregate these findings to identify consistent factors across musculoskeletal disorders that are associated with the development of CMP. The objective of this study is to provide a meta-level synthesis of all biopsychosocial factors associated with the development of CMP.
An umbrella review and meta-level narrative synthesis±meta-analysis has been designed informed by Joanna Briggs Institute and Cochrane guidance. This protocol is reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-P. Sources will include Ovid Medline, Embase, Web of Science Core Collection, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, PsycINFO, CINAHL, PEDro, PROSPERO, Google Scholar and grey literature.
any systematic review which investigates biopsychosocial factors which may be associated with the development of CMP through prospective longitudinal methods. The outcome is musculoskeletal pain lasting beyond 3 months. Two independent reviewers will be involved in all stages; screening, selection, data extraction and risk of bias evaluation using the Assessing the Methodological Quality of Systematic Reviews-2 guidelines. A meta-level narrative synthesis will be conducted based on (a) factors associated with development of CMP, (b) the range of musculoskeletal disorders for which the same/similar findings have been established and (c) the quality of studies informing these findings. Where possible, meta-analysis will be performed. The Grading of Recommendations, Assessment, Development and Evaluation guidelines will be followed to determine the level of evidence for each biopsychosocial factor.
This umbrella review does not require ethical approval. Findings will be presented at conferences and published in a peer reviewed journal.
CRD42020193081.
最近的系统评价已经确定了许多与慢性肌肉骨骼疼痛（CMP）发展相关的生物心理社会因素。尽管这些因素通常特定于某种特定的肌肉骨骼疾病，但在系统评价中发现的结果是相似的。需要研究来汇总这些发现，以确定与 CMP 发展相关的肌肉骨骼疾病之间一致的因素。本研究的目的是对与 CMP 发展相关的所有生物心理社会因素进行元水平综合。
本研究采用循证卫生保健中心的循证医学纳扎雷特综述和元水平叙述性综合±元分析设计，并参考了 Joanna Briggs 研究所和 Cochrane 指南。本方案按照系统评价和荟萃分析的首选报告项目（PRISMA）报告。来源将包括 Ovid Medline、Embase、Web of Science 核心合集、Cochrane 系统评价数据库、效应摘要数据库、PsycINFO、CINAHL、PEDro、PROSPERO、Google Scholar 和灰色文献。
任何通过前瞻性纵向方法调查可能与 CMP 发展相关的生物心理社会因素的系统评价。结局是持续超过 3 个月的肌肉骨骼疼痛。两名独立的审查员将参与所有阶段；使用评估系统评价方法学质量-2 指南进行筛选、选择、数据提取和偏倚风险评估。将根据以下三个方面进行元水平叙述性综合：（a）与 CMP 发展相关的因素，（b）已经确定相同/类似发现的肌肉骨骼疾病范围，（c）为这些发现提供信息的研究质量。在可能的情况下，将进行荟萃分析。将遵循推荐、评估、制定和评估分级指南来确定每个生物心理社会因素的证据水平。
本伞式评价不需要伦理批准。研究结果将在会议上展示，并发表在同行评议的期刊上。
PROSPERO 注册号：CRD42020193081。
