Fregly M J, Lockley O E, Cade J R
Department of Physiology, University of Florida, College of Medicine, Gainesville.
Pharmacology. 1988;36(2):91-100. doi: 10.1159/000138364.
Chronic dietary administration of L-tryptophan (2.5 and 5.0 g/100 g food) to rats provided significant protection against the development of hypertension induced by bilateral encapsulation of the kidneys with latex envelopes. Lower doses of tryptophan (0.5 and 1.0 g/100 g food) attenuated the rate of elevation of blood pressure, but failed to maintain systolic blood pressures at levels significantly below that of untreated renal hypertensive controls. The body weight of the rats was not affected significantly by treatment with any dose of tryptophan used. Chronic treatment with tryptophan also protected against the reduced urinary concentrating ability during a 24-hour dehydration that characteristically accompanies renal encapsulation. A modest (5-8%) effect of treatment to reduce cardiac hypertrophy was also observed. The mechanism of the antihypertensive effect of tryptophan is not revealed by these studies although they rule out the possibilities that reduction in sodium intake and/or reduction in body weight may be important factors.
长期给大鼠喂食L-色氨酸（2.5克/100克食物和5.0克/100克食物）可显著保护其免受因用乳胶包膜双侧包裹肾脏所诱发的高血压的影响。较低剂量的色氨酸（0.5克/100克食物和1.0克/100克食物）减缓了血压升高的速率，但未能将收缩压维持在显著低于未治疗的肾性高血压对照组的水平。所用任何剂量的色氨酸处理均未对大鼠体重产生显著影响。色氨酸的长期治疗还可防止在肾包膜包裹特有的24小时脱水期间出现的尿浓缩能力降低。还观察到治疗对减轻心脏肥大有适度（5 - 8%）的效果。尽管这些研究排除了钠摄入量减少和/或体重减轻可能是重要因素的可能性，但色氨酸的降压作用机制尚未揭示。
