Department of Mental Health, Local Health Service, Parma, Italy; Department of Neuroscience, Psychiatric Unit, University of Parma, Parma, Italy.
Department of Neuroscience, Psychiatric Unit, University of Parma, Parma, Italy.
Psychiatry Res. 2021 Mar;297:113715. doi: 10.1016/j.psychres.2021.113715. Epub 2021 Jan 22.
Apparent comorbidity between Bipolar Disorder (BD) and Obsessive-Compulsive Disorder (OCD) is a common condition, but its meaning has not been clarified yet. The present study aimed to evaluate the pattern of occurrence of obsessive-compulsive symptoms (OCS) in the different phases of BD. One hundred and sixty-five BD patients, 62 (37.5%) euthymic, 34 (20.6%) in hypomanic/manic phase, 43 (26%) in depressive phase and 26 (15.7%) in mixed state, were assessed with the Yale-Brown Obsessive-Compulsive Scale (YBOCS), the Hamilton Depression Rating Scale (HAM-D), the Young Mania Rating Scale (YMRS) and the Ruminative Response Scale (RRS). In the whole sample, the severity of OCS was associated to the severity of depressive symptoms. The highest severity of OCS (YBOCS total score) was observed in the mixed group and the lowest scores in the hypomanic/manic group. Our findings suggest that OCS in BD patients appear as a state-dependent phenomenon cycling with the mood phases, particularly exacerbating in the context of depressive and mixed states.
双相障碍（BD）和强迫症（OCD）之间明显的共病是一种常见的情况，但它的含义尚未阐明。本研究旨在评估在 BD 的不同阶段出现强迫症状（OCS）的模式。评估了 165 名 BD 患者，其中 62 名（37.5%）处于缓解期，34 名（20.6%）处于轻躁狂/躁狂期，43 名（26%）处于抑郁期，26 名（15.7%）处于混合状态，采用耶鲁-布朗强迫量表（YBOCS）、汉密尔顿抑郁评定量表（HAM-D）、杨氏躁狂评定量表（YMRS）和反刍反应量表（RRS）进行评估。在整个样本中，OCS 的严重程度与抑郁症状的严重程度相关。OCS 的严重程度最高（YBOCS 总分）出现在混合组，而在轻躁狂/躁狂组的得分最低。我们的研究结果表明，BD 患者的 OCS 表现为一种与情绪阶段相关的状态依赖性现象，特别是在抑郁和混合状态下加重。
