载脂蛋白 B 从内质网搭乘“便车”到高尔基体。
ApoB SURFs a Ride from the ER to the Golgi.
机构信息
Department of Medicine, Vagelos College of Physicians and Surgeons of Columbia University, New York, NY, USA.
出版信息
Cell Metab. 2021 Feb 2;33(2):231-233. doi: 10.1016/j.cmet.2021.01.007.
Chylomicrons and very-low-density lipoproteins (VLDLs) are large, complex cargos that may require specific chaperones for efficient transport from the ER to Golgi. In this issue of Cell Metabolism, Wang et al. (2020) identify SURF4, in coordination with SAR1B, as an essential player in COPII transport of VLDLs from ER to Golgi, suggesting that SURF4 may be a target for approaches aimed at reducing secretion of triglyceride-rich, atherogenic lipoproteins from the liver.
乳糜微粒和极低密度脂蛋白（VLDLs）是大型、复杂的货物，可能需要特定的伴侣蛋白来实现从内质网到高尔基体的有效运输。在本期《细胞代谢》中，Wang 等人（2020）发现 SURF4 与 SAR1B 协调作用，是 VLDL 从内质网到高尔基体的 COPII 运输所必需的，这表明 SURF4 可能是一种针对降低肝脏中富含甘油三酯、致动脉粥样硬化脂蛋白分泌的方法的靶点。
Zotero 插件