• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Novel Targets and Mechanisms in Antimicrobial Drug Discovery.抗菌药物研发中的新靶点与机制
Antibiotics (Basel). 2021 Feb 1;10(2):141. doi: 10.3390/antibiotics10020141.
2
Challenges in antimicrobial drug discovery and the potential of nucleoside antibiotics.抗菌药物研发面临的挑战及核苷类抗生素的潜力
Curr Med Chem. 2004 Mar;11(6):775-93. doi: 10.2174/0929867043455774.
3
Strategies for discovery of new molecular targets for anti-infective drugs.抗感染药物新的分子靶标的发现策略。
Curr Opin Pharmacol. 2019 Oct;48:57-68. doi: 10.1016/j.coph.2019.04.015. Epub 2019 May 28.
4
Protein-protein complexes as targets for drug discovery against infectious diseases.蛋白质-蛋白质复合物作为抗传染病药物发现的靶标。
Adv Protein Chem Struct Biol. 2020;121:237-251. doi: 10.1016/bs.apcsb.2019.11.012. Epub 2019 Dec 18.
5
Antimicrobial Peptides: A Promising Therapeutic Strategy in Tackling Antimicrobial Resistance.抗菌肽:应对抗菌耐药性的一种有前景的治疗策略。
Curr Med Chem. 2017;24(38):4303-4314. doi: 10.2174/0929867324666170815102441.
6
Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics.大环化合物作为潜在抗感染治疗药物的发现方面的最新进展。
Curr Med Chem. 2009;16(1):42-65. doi: 10.2174/092986709787002844.
7
Drosophila melanogaster as a model host for the study of microbial pathogenicity and the discovery of novel antimicrobial compounds.黑腹果蝇作为研究微生物致病性和发现新型抗菌化合物的模式宿主。
Curr Pharm Des. 2011;17(13):1246-53. doi: 10.2174/138161211795703744.
8
Methicillin-Resistant in Diabetic Foot Infection in India: A Growing Menace.印度糖尿病足感染中的耐甲氧西林情况:日益严重的威胁。
Int J Low Extrem Wounds. 2019 Sep;18(3):236-246. doi: 10.1177/1534734619853668. Epub 2019 Jul 1.
9
Current and future challenges in the development of antimicrobial agents.抗菌药物研发中的当前及未来挑战
Handb Exp Pharmacol. 2012(211):45-65. doi: 10.1007/978-3-642-28951-4_4.
10
The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs.对抗耐药性疟疾:新型疟原虫靶点与抗疟药物
Curr Med Chem. 2008;15(2):161-71. doi: 10.2174/092986708783330575.

引用本文的文献

1
Anti-staphylococcal activity, antibiotic-resistance modulation effects and action of Harungana madagascariensis (Hypericaceae) fruit extracts on the antioxidant system of multidrug-resistant Staphylococcus aureus.马达加斯加金丝桃(金丝桃科)果实提取物对耐多药金黄色葡萄球菌的抗葡萄球菌活性、抗生素耐药性调节作用及对其抗氧化系统的影响
PLoS One. 2025 Aug 7;20(8):e0329771. doi: 10.1371/journal.pone.0329771. eCollection 2025.
2
Salmonella stress response systems as targets for anti-virulence strategies.沙门氏菌应激反应系统作为抗毒力策略的靶点。
BMC Microbiol. 2025 Jul 2;25(1):378. doi: 10.1186/s12866-025-04003-6.
3
Therapeutic Target Identification and Inhibitor Screening against Riboflavin Synthase of Colorectal Cancer Associated .针对结直肠癌相关核黄素合酶的治疗靶点鉴定与抑制剂筛选
Cancers (Basel). 2022 Dec 19;14(24):6260. doi: 10.3390/cancers14246260.
4
Overview on Strategies and Assays for Antibiotic Discovery.抗生素发现的策略与检测方法综述
Pharmaceuticals (Basel). 2022 Oct 21;15(10):1302. doi: 10.3390/ph15101302.
5
Isolation and characterization of lytic bacteriophages from sewage at an egyptian tertiary care hospital against methicillin-resistant clinical isolates.从埃及一家三级护理医院的污水中分离并鉴定针对耐甲氧西林临床分离株的裂解性噬菌体。
Saudi J Biol Sci. 2022 May;29(5):3097-3106. doi: 10.1016/j.sjbs.2022.03.019. Epub 2022 Mar 19.

本文引用的文献

1
Riboswitches as Drug Targets for Antibiotics.核糖开关作为抗生素的药物靶点
Antibiotics (Basel). 2021 Jan 5;10(1):45. doi: 10.3390/antibiotics10010045.
2
Anticapsular and Antifungal Activity of α-Cyperone.α-香附酮的抗荚膜和抗真菌活性。
Antibiotics (Basel). 2021 Jan 6;10(1):51. doi: 10.3390/antibiotics10010051.
3
A New Promising Anti-Infective Agent Inhibits Biofilm Growth by Targeting Simultaneously a Conserved RNA Function That Controls Multiple Genes.一种有前景的新型抗感染药物通过同时靶向一种控制多个基因的保守RNA功能来抑制生物膜生长。
Antibiotics (Basel). 2021 Jan 4;10(1):41. doi: 10.3390/antibiotics10010041.
4
Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?我们能否利用β-内酰胺酶的内在动力学来设计更有效的抑制剂?
Antibiotics (Basel). 2020 Nov 21;9(11):833. doi: 10.3390/antibiotics9110833.
5
Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin.酰胺螯合心菌素克服了对四环素和天然螯合心菌素产生的耐药机制。
Antibiotics (Basel). 2020 Sep 18;9(9):619. doi: 10.3390/antibiotics9090619.
6
Overcoming Intrinsic and Acquired Resistance Mechanisms Associated with the Cell Wall of Gram-Negative Bacteria.克服与革兰氏阴性菌细胞壁相关的固有和获得性耐药机制。
Antibiotics (Basel). 2020 Sep 19;9(9):623. doi: 10.3390/antibiotics9090623.
7
Synthesis, ADMET Properties, and In Vitro Antimicrobial and Antibiofilm Activity of 5-Nitro-2-thiophenecarbaldehyde N-((E)-(5-Nitrothienyl)methylidene)hydrazone (KTU-286) against with Defined Resistance Mechanisms.5-硝基-2-噻吩甲醛N-((E)-(5-硝基噻吩基)亚甲基)腙(KTU-286)的合成、ADMET性质、体外抗菌和抗生物膜活性及其对特定耐药机制的作用
Antibiotics (Basel). 2020 Sep 17;9(9):612. doi: 10.3390/antibiotics9090612.
8
Indoline-6-Sulfonamide Inhibitors of the Bacterial Enzyme DapE.细菌酶DapE的吲哚啉-6-磺酰胺抑制剂
Antibiotics (Basel). 2020 Sep 11;9(9):595. doi: 10.3390/antibiotics9090595.
9
Anti-Tubercular Properties of 4-Amino-5-(4-Fluoro-3- Phenoxyphenyl)-4-1,2,4-Triazole-3-Thiol and Its Schiff Bases: Computational Input and Molecular Dynamics.4-氨基-5-(4-氟-3-苯氧基苯基)-4H-1,2,4-三唑-3-硫醇及其席夫碱的抗结核特性:计算输入与分子动力学
Antibiotics (Basel). 2020 Aug 31;9(9):559. doi: 10.3390/antibiotics9090559.
10
Ceftazidime-Avibactam Combination Therapy Compared to Ceftazidime-Avibactam Monotherapy for the Treatment of Severe Infections Due to Carbapenem-Resistant Pathogens: A Systematic Review and Network Meta-Analysis.头孢他啶-阿维巴坦联合治疗与头孢他啶-阿维巴坦单药治疗对碳青霉烯类耐药病原体所致严重感染的疗效比较:一项系统评价和网状Meta分析
Antibiotics (Basel). 2020 Jul 7;9(7):388. doi: 10.3390/antibiotics9070388.

抗菌药物研发中的新靶点与机制

Novel Targets and Mechanisms in Antimicrobial Drug Discovery.

作者信息

Tondi Donatella

机构信息

Department of Life Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy.

出版信息

Antibiotics (Basel). 2021 Feb 1;10(2):141. doi: 10.3390/antibiotics10020141.

DOI:10.3390/antibiotics10020141
PMID:33535514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7912713/
Abstract

The spread of infections resistant to available anti-infective drugs is a serious menace to human health [...].

摘要

对现有抗感染药物产生耐药性的感染传播对人类健康构成严重威胁[……]。