营养风险对慢性阻塞性肺疾病患者认知功能的影响。
Effect of nutritional risk on cognitive function in patients with chronic obstructive pulmonary disease.
作者信息
Huang Yiben, Ma Jiedong, Jiang Bingqian, Yang Naiping, Fu Fangyi, Chen Xianjing, Liu Chunyan, Miao Xiaqi, Mao Huanhuan, Zheng Rongrong, Wang Jianing, Ding Keke, Zhang Xiaodiao
机构信息
Department of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China.
出版信息
J Int Med Res. 2021 Feb;49(2):300060521990127. doi: 10.1177/0300060521990127.
OBJECTIVE
We aimed to clarify the cognitive function of patients with chronic obstructive pulmonary disease (COPD) and different nutritional status.
METHODS
Among 95 patients with COPD in this retrospective study, we administered the Nutritional Risk Screening 2002 (NRS 2002) and Mini-Mental State Examination (MMSE). We recorded patients' clinical characteristics, comorbidities, and laboratory measurements. According to NRS 2002 scores, patients were divided into two groups: no nutritional risk with NRS 2002 < 3 ( = 54) and nutritional risk, with NRS 2002 ≥ 3 ( = 41).
RESULTS
We found a negative correlation between NRS 2002 and MMSE scores in participants with COPD ( = -0.313). Patients with nutritional risk were more likely to be cognitively impaired than those with no nutritional risk. Multivariate logistic regression analysis indicated that malnutrition was an independent risk factor for cognitive impairment, after adjusting for confounders (odds ratio [OR] = 4.120, 95% confidence interval [CI]: 1.072-15.837). We found a similar association between NRS 2002 and MMSE scores at 90-day follow-up using a Pearson's correlation test ( = -0.493) and logistic regression analysis (OR = 7.333, 95% CI: 1.114-48.264).
CONCLUSIONS
Patients with COPD at nutritional risk are more likely to have cognitive impairment.
目的
我们旨在阐明慢性阻塞性肺疾病（COPD）患者以及不同营养状况患者的认知功能。
方法
在这项回顾性研究的95例COPD患者中，我们进行了营养风险筛查2002（NRS 2002）和简易精神状态检查表（MMSE）。我们记录了患者的临床特征、合并症和实验室测量结果。根据NRS 2002评分，患者被分为两组：NRS 2002＜3（n = 54）无营养风险组和NRS 2002≥3（n = 41）营养风险组。
结果
我们发现COPD参与者中NRS 2002与MMSE评分之间呈负相关（r = -0.313）。与无营养风险的患者相比，有营养风险的患者更易出现认知障碍。多因素逻辑回归分析表明，在调整混杂因素后，营养不良是认知障碍的独立危险因素（比值比[OR] = 4.120，95%置信区间[CI]：1.072 - 15.837）。在90天随访时，我们通过Pearson相关检验（r = -0.493）和逻辑回归分析（OR = 7. .333，95% CI：1.114 - 48.264）发现NRS 2002与MMSE评分之间存在类似关联。
结论
有营养风险的COPD患者更易出现认知障碍。
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