Paavolainen P, Taivainen T, Holmström T, Roberts P J, Penttinen R
Surgical Hospital, Division of Orthopedic Surgery and Traumatology, University Central Hospital, Helsinki, Finland.
Res Exp Med (Berl). 1988;188(1):41-8. doi: 10.1007/BF01852093.
The effects of systemically administered calcitonin (CT) on granulation tissue development were compared using viscose cellulose sponges as wound model in the rat. The ingrowth of new granulation tissue was analyzed for the contents of various connective tissue components (total nitrogen, hydroxyproline, DNA, and RNA) and for the differential counts of the cells infiltrating the sponges. The results indicate that up to 4 weeks postoperatively (p.o.) CT did not affect the net amount of collagen, measured as hydroxyproline, total nitrogen, aminosugars nor the dynamics of differentiation and viability of the invading cells. The present observation that CT has negligible effects, if any, on the early stages of connective tissue formation and on the cell population indicates that surgical procedures could be carried out safely during systemic CT therapy without an increased risk of wound complications.
在大鼠中，使用粘胶纤维素海绵作为伤口模型，比较了全身给药降钙素（CT）对肉芽组织发育的影响。分析新肉芽组织向内生长的各种结缔组织成分（总氮、羟脯氨酸、DNA和RNA）含量，以及浸润海绵的细胞分类计数。结果表明，术后长达4周，CT对以羟脯氨酸、总氮、氨基糖衡量的胶原蛋白净含量，以及对侵入细胞的分化和活力动态均无影响。目前的观察结果表明，CT对结缔组织形成的早期阶段和细胞群体的影响（如果有影响的话）可以忽略不计，这表明在全身CT治疗期间可以安全地进行外科手术，而不会增加伤口并发症的风险。
