鸢尾素对种植失败大鼠 LIF 和整合素 αvβ3 的影响。
Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure.
机构信息
Department of Traditional Chinese Medicine, Affliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, P.R. China.
Hubei Key Laboratory of Wudang Local Chinese Medicine Research, School of Pharmaceutical Sciences, Hubei University of Medicine, Shiyan, Hubei, 442000, P.R. China.
出版信息
Reprod Biol Endocrinol. 2021 Feb 3;19(1):18. doi: 10.1186/s12958-021-00700-9.
OBJECTIVE
The aim of this study is to investigate the effect of irisin on leukemia inhibitory factor (LIF) and integrin αvβ3 in implantation failure uterus.
METHODS
Early pregnant rats were randomly divided into normal group (N), mifepristone treated group (M), irisin group (I) and progestin group (P). The implantation failure model was established using mifepristone. Second, we evaluated the average number of embryos and detected the expression of LIF and integrin αvβ3 protein and mRNA in endometrium.
RESULTS
Compared with group M, the average number of embryos was significantly higher in group N, P and I, the expression of LIF and integrin αvβ3 in endometrium was significantly higher in group N, P and I.
CONCLUSION
Irisin could improve the poor receptive state of endometrium by promoting LIF and integrin αvβ3 secretion to improve blastocyst implantation in rats of implantation failure.
目的
本研究旨在探讨鸢尾素对植入失败子宫中白血病抑制因子（LIF）和整合素αvβ3 的影响。
方法
将早孕大鼠随机分为正常组（N）、米非司酮处理组（M）、鸢尾素组（I）和孕激素组（P）。用米非司酮建立植入失败模型。其次，我们评估了胚胎的平均数量，并检测了子宫内膜中 LIF 和整合素αvβ3 蛋白和 mRNA 的表达。
结果
与 M 组相比，N 组、P 组和 I 组胚胎平均数量明显增加，N 组、P 组和 I 组子宫内膜中 LIF 和整合素αvβ3 的表达明显增加。
结论
鸢尾素通过促进 LIF 和整合素αvβ3 的分泌，改善植入失败大鼠的子宫内膜容受性，从而提高囊胚的着床。
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