Department of Endocrinology and Metabolism, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Department of Cardiology (Campus Benjamin Franklin), Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Sci Rep. 2021 Feb 3;11(1):2906. doi: 10.1038/s41598-021-81084-z.
Low handgrip strength and increased arterial stiffness are both associated with poor health outcomes, but evidence on the relationship between handgrip strength and arterial stiffness is limited. In this cross-sectional analysis of combined baseline datasets from the LipidCardio and Berlin Aging Study II cohorts we aimed to examine whether handgrip strength (HGS) is associated with arterial stiffness. 1511 participants with a median age of 68.56 (IQR 63.13-73.08) years were included. Arterial stiffness was assessed by aortal pulse wave velocity (PWV) with the Mobil-O-Graph device. Handgrip strength was assessed with a handheld dynamometer.The mean HGS was 39.05 ± 9.07 kg in men and 26.20 ± 7.47 kg in women. According to multivariable linear regression analysis per 5 kg decrease in handgrip strength there was a mean increase in PWV of 0.08 m/s after adjustment for the confounders age, sex, coronary artery disease, systolic blood pressure, body mass index, cohort, and smoking. Thus, there was evidence that low handgrip strength and increased arterial stiffness go hand in hand. Arterial stiffness can possibly create the missing link between low handgrip strength and increased cardiovascular morbidity and mortality. Causality and direction of causality remain to be determined.
握力低和动脉僵硬度增加都与健康状况不佳有关，但有关握力与动脉僵硬之间关系的证据有限。在这项脂质心脏研究和柏林老龄化研究 II 队列的联合基线数据集的横断面分析中，我们旨在研究握力（HGS）是否与动脉僵硬度相关。纳入了 1511 名中位年龄为 68.56（IQR 63.13-73.08）岁的参与者。使用 Mobil-O-Graph 设备通过主动脉脉搏波速度（PWV）评估动脉僵硬度。使用手持测力计评估握力。男性的平均 HGS 为 39.05 ± 9.07 kg，女性为 26.20 ± 7.47 kg。根据多变量线性回归分析，在调整混杂因素（年龄、性别、冠心病、收缩压、体重指数、队列和吸烟）后，握力每降低 5 kg，PWV 平均增加 0.08 m/s。因此，有证据表明握力低和动脉僵硬度增加是相互关联的。动脉僵硬度可能是握力低与心血管发病率和死亡率增加之间缺失的环节。因果关系和因果关系的方向仍有待确定。
