Furuya Tomoki, Kitahama Shinji, Tamura Yuma, Ogawa Susumu, Nakatani Yuki, Yasu Takanori
Department of Cardiovascular Medicine and Nephrology, Dokkyo Medical University Nikko Medical Center, Nikko, JPN.
Research Team for Social Participation and Healthy Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi, JPN.
Cureus. 2024 Sep 3;16(9):e68561. doi: 10.7759/cureus.68561. eCollection 2024 Sep.
Background We defined the progression of atherosclerosis in patients by brachial-ankle pulse wave velocity (ba-PWV) and determined the relationship between ba-PWV and body composition factors, muscle strength, and patient characteristics. Methodology The arterial stiffness index, body composition, anthropometric parameters, blood test data, and background factors were evaluated in 109 patients with type 2 diabetes mellitus (T2DM). Statistical analysis was conducted using logistic regression analysis and analysis of covariance (p < 0.05). Results The mean age of the participants was 62.87 ± 12.11 years, body mass index (BMI) was 25.72 ± 4.35 kg/m², ba-PWV was 1653.08 ± 366.55 cm/s, systolic blood pressure was 138.87 ± 16.74 mmHg, the number of years of disease was 11.17 ± 9.51 years, and hemoglobin A1c value was 6.90 ± 0.74%. Binomial logistic regression analysis of ba-PWV divided into two groups by arterial stiffness index, ≥ (or <) 1,400 cm/s, showed systolic blood pressure (odds ratio = 1.11, 95% confidence interval = 1.05-1.18, p < 0.001), BMI, and number of years of disease were significant independent variables. The cut-off value for BMI was 26.28 kg/m². BMI was a significant explanatory factor for ba-PWV in the analysis of covariance (p < 0.001). Conclusion BMI was associated with the incidence of atherosclerosis in patients with T2DM. We proposed a cut-off value for BMI below which the atherosclerosis index increased, a result that may reflect the influence of the metabolic paradox.
我们通过臂踝脉搏波速度（ba-PWV）定义患者动脉粥样硬化的进展情况，并确定ba-PWV与身体成分因素、肌肉力量及患者特征之间的关系。方法：对109例2型糖尿病（T2DM）患者的动脉僵硬度指数、身体成分、人体测量参数、血液检测数据及背景因素进行评估。采用逻辑回归分析和协方差分析进行统计分析（p<0.05）。结果：参与者的平均年龄为62.87±12.11岁，体重指数（BMI）为25.72±4.35kg/m²，ba-PWV为1653.08±366.55cm/s，收缩压为138.87±16.74mmHg，病程为11.17±9.51年，糖化血红蛋白值为6.90±0.74%。根据动脉僵硬度指数将ba-PWV分为两组，≥（或<）1400cm/s，二项逻辑回归分析显示收缩压（比值比=1.11，95%置信区间=1.05-1.18，p<0.001）、BMI和病程是显著的独立变量。BMI的截断值为26.28kg/m²。在协方差分析中，BMI是ba-PWV的显著解释因素（p<0.001）。结论：BMI与T2DM患者动脉粥样硬化的发生有关。我们提出了一个BMI的截断值，低于该值动脉粥样硬化指数会升高，这一结果可能反映了代谢悖论的影响。
