Qiu Tong, Yang Kaiying, Dai Shiyi, Chen Siyuan, Ji Yi
Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu 610041, People's Republic of China.
Pediatric Intensive Care Unit, Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu 610041, People's Republic of China.
Ther Clin Risk Manag. 2021 Jan 27;17:119-125. doi: 10.2147/TCRM.S291059. eCollection 2021.
Infantile hemangioma (IH) is the most common benign tumor in children. However, few studies have reported the clinical features of segmental IH. We aimed to determine the clinical characteristics of segmental IH and to identify features that may aid clinicians in managing segmental IH.
In the cross-sectional prospective study approved by the Ethics Committee of the hospital, children diagnosed with IH were recruited, and information including patient demographics, IH morphology and anatomical location, complications and treatments were recorded and analyzed.
In total, 153 patients with segmental IH and 1375 patients with nonsegmental IH were enrolled in this study. The average age on the day of the first visit in patients with segmental IH was 3.63±3.23 months. In 69 patients (45.10%), segmental IH was diagnosed at birth. Most segmental IHs (49.67%) occurred in the limbs, while only 22.04% of nonsegmental IHs occurred in the extremities (<0.001). Thirteen patients (8.50%) with segmental IH had ulceration. Compared with patients with nonsegmental IHs, patients with segmental IHs were more likely to be treated with oral drugs (<0.001).
Segmental IHs mainly occur in the extremities and are frequently diagnosed at birth. Segmental IHs are usually accompanied by ulceration, which are more commonly seen in the neck and perineal/perianal/genital areas than nonsegmental IHs. Oral propranolol is prescribed more often in patients with segmental IH than in those with nonsegmental IH.
婴儿血管瘤（IH）是儿童最常见的良性肿瘤。然而，很少有研究报道节段性IH的临床特征。我们旨在确定节段性IH的临床特征，并识别有助于临床医生管理节段性IH的特征。
在医院伦理委员会批准的横断面前瞻性研究中，招募被诊断为IH的儿童，并记录和分析包括患者人口统计学、IH形态和解剖位置、并发症及治疗等信息。
本研究共纳入153例节段性IH患者和1375例非节段性IH患者。节段性IH患者首次就诊当天的平均年龄为3.63±3.23个月。69例（45.10%）节段性IH在出生时被诊断。大多数节段性IH（49.67%）发生在四肢，而非节段性IH仅22.04%发生在四肢（<0.001）。13例（8.50%）节段性IH患者出现溃疡。与非节段性IH患者相比，节段性IH患者更有可能接受口服药物治疗（<0.001）。
节段性IH主要发生在四肢，且常在出生时被诊断。节段性IH通常伴有溃疡，在颈部和会阴/肛周/生殖器区域比非节段性IH更常见。节段性IH患者比非节段性IH患者更常使用口服普萘洛尔。
