Shin Dong Ah, Kim Tae Uk, Chang Min Cheol
Department of Neurosurgery, Yonsei University, College of Medicine, Seoul, Republic of Korea.
Department of Physical Medicine and Rehabilitation, College of Medicine, Dankook University, Cheonan, Republic of Korea.
J Pain Res. 2021 Jan 26;14:139-145. doi: 10.2147/JPR.S292824. eCollection 2021.
Minocycline is known to reduce microglial activation, suggesting that it may reduce neuropathic pain. We reviewed studies in humans that evaluated the effectiveness of minocycline in alleviating neuropathic pain.
We searched the PubMed, Embase, Cochrane library, and SCOPUS databases for papers published before January 06, 2021, using the search words minocycline and pain. The inclusion criteria for the selection of articles were (1) minocycline administered to humans and (2) minocycline administered to control neuropathic pain.
The primary literature search yielded 2299 relevant papers. Based on the assessment of the titles, abstracts, and full-text, nine publications were selected for this review. Only four of the nine studies showed a positive pain-reducing outcome after minocycline administration. Two of the three studies on chemotherapy-induced neuropathic pain showed a positive pain-reducing effect. Minocycline was effective in controlling pain from diabetic and leprotic neuropathies. However, minocycline was not effective in controlling lumbar radicular pain and pain resolution after carpal tunnel release.
Our review provides evidence that minocycline may have some potential for reducing neuropathic pain. Further high-quality studies need to be conducted to validate this potential.
已知米诺环素可减轻小胶质细胞活化，提示其可能减轻神经性疼痛。我们回顾了评估米诺环素减轻神经性疼痛有效性的人体研究。
我们在PubMed、Embase、Cochrane图书馆和SCOPUS数据库中检索2021年1月6日前发表的论文，检索词为米诺环素和疼痛。文章选择的纳入标准为：（1）对人体施用米诺环素；（2）施用米诺环素以控制神经性疼痛。
初步文献检索得到2299篇相关论文。基于对标题、摘要和全文的评估，选择了9篇出版物进行本综述。9项研究中只有4项显示施用米诺环素后有减轻疼痛的积极结果。3项关于化疗引起的神经性疼痛的研究中有2项显示有减轻疼痛的积极效果。米诺环素对控制糖尿病性和麻风性神经病变引起的疼痛有效。然而，米诺环素对控制腰神经根性疼痛和腕管松解术后的疼痛缓解无效。
我们的综述提供了证据表明米诺环素在减轻神经性疼痛方面可能有一定潜力。需要进一步开展高质量研究来验证这一潜力。
