细颗粒物（PM.）促进肺泡上皮细胞中CD146表达及肺部感染。

Fine Particulate Matter (PM.) Promotes CD146 Expression in Alveolar Epithelial Cells and Pulmonary Infection.

作者信息

Sun Zhixiao, Ji Ningfei, Jiang Jingxian, Tao Yuan, Zhang Enrui, Yang Xiaofan, Wang Zhengxia, Chen Zhongqi, Huang Mao, Zhang Mingshun

机构信息

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

NHC Key Laboratory of Antibody Technique, Department of Immunology, Nanjing Medical University, Nanjing, China.

出版信息

Front Microbiol. 2021 Jan 18;11:525976. doi: 10.3389/fmicb.2020.525976. eCollection 2020.

Air pollution is a leading cause of increasing infectious lung diseases. Pulmonary cryptococcosis is a fatal fungal pneumonia in acquired immunodeficiency syndrome patients. In some cases, the pathogen also develops dormant nodules in immunocompetent individuals. In the present study, we demonstrated that fine particulate matter (PM.) increased CD146 expression in alveolar epithelial cells and promoted pulmonary infection. Aryl hydrocarbon receptor (AhR) signaling was required for increased expression of CD146 in epithelial cells treated with PM.. In a murine model of pulmonary infection, PM. promoted fungal infection, and CD146 deficiency decreased the fugal burden of . Our study may highlight the importance of air pollution to lung mycosis and CD146 as a target for preventing infectious lung diseases.

空气污染是导致传染性肺部疾病增加的主要原因。肺隐球菌病是获得性免疫缺陷综合征患者中一种致命的真菌性肺炎。在某些情况下，该病原体也会在免疫功能正常的个体中形成潜伏结节。在本研究中，我们证明细颗粒物（PM.）增加了肺泡上皮细胞中CD146的表达并促进了肺部感染。在用PM.处理的上皮细胞中，芳烃受体（AhR）信号传导是CD146表达增加所必需的。在肺部感染的小鼠模型中，PM.促进真菌感染，而CD146缺陷降低了.的真菌负荷。我们的研究可能凸显了空气污染对肺真菌病的重要性以及CD146作为预防传染性肺部疾病靶点的重要性。