Choi Ji Min, Chung Goh Eun, Kang Seung Joo, Kwak Min-Sun, Yang Jong In, Park Boram, Yim Jeong Yoon
Department of Internal Medicine and Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea.
Department of Public Health Sciences, Seoul National University, Seoul, South Korea.
Front Med (Lausanne). 2021 Jan 18;7:585618. doi: 10.3389/fmed.2020.585618. eCollection 2020.
Depression and anxiety disorder are frequently seen in patients with nonalcoholic fatty liver disease (NAFLD). However, the associations between mood disorders and NAFLD have not been fully evaluated. In this study, we investigated the relationship between NAFLD and depression or anxiety in a Korean population. We conducted a retrospective cross-sectional study that included subjects who underwent abdominal ultrasonography and completed a symptom questionnaire for a routine health check-up. NAFLD was diagnosed and graded according to the ultrasonography findings. Depression and anxiety were assessed using the Beck Depression Inventory and State-Trait Anxiety Inventory, respectively. Among the total of 25,333 subjects, the mean age was 47 years (men, 56.2%), and the prevalence rate of NAFLD was 30.9%. In the multivariate analysis, NAFLD showed a significant association with depression [adjusted odds ratio (OR) 1.43 and 95% confidence interval (CI) 1.14-1.80, = 0.002] in women. Severe NAFLD significantly correlated with state anxiety and trait anxiety (adjusted OR 1.84 and 95% CI 1.01-3.37, = 0.047 and adjusted OR 2.45 and 95% CI 1.08-4.85, = 0.018, respectively) in women. There was a higher tendency of women with NAFLD to suffer from depression with increase in steatosis, and severe stage of steatosis was significantly associated with anxiety in the female compared to non-NAFLD. Understanding the association between NAFLD and mood disorders may have clinical implications for reducing the prevalence of comorbidities.
抑郁症和焦虑症在非酒精性脂肪性肝病（NAFLD）患者中很常见。然而，情绪障碍与NAFLD之间的关联尚未得到充分评估。在本研究中，我们调查了韩国人群中NAFLD与抑郁或焦虑之间的关系。我们进行了一项回顾性横断面研究，纳入了接受腹部超声检查并完成常规健康检查症状问卷的受试者。根据超声检查结果诊断并分级NAFLD。分别使用贝克抑郁量表和状态-特质焦虑量表评估抑郁和焦虑。在总共25333名受试者中，平均年龄为47岁（男性占56.2%），NAFLD患病率为30.9%。在多变量分析中，NAFLD在女性中与抑郁症有显著关联[调整后的优势比（OR）为1.43，95%置信区间（CI）为1.14 - 1.80，P = 0.002]。在女性中，重度NAFLD与状态焦虑和特质焦虑显著相关（调整后的OR分别为1.84，95%CI为1.01 - 3.37，P = 0.047；调整后的OR为2.45，95%CI为1.08 - 4.85，P = 0.018）。与非NAFLD相比，患有NAFLD的女性随着脂肪变性增加患抑郁症的倾向更高，并且重度脂肪变性阶段与女性焦虑显著相关。了解NAFLD与情绪障碍之间的关联可能对降低合并症的患病率具有临床意义。
